Cover Image

Diagnostic accuracy and feasibility of patient self-testing with a SARS-CoV-2 antigen-detecting rapid test

Background - Considering the possibility of nasal self-sampling and the ease of use in performing SARS-CoV-2 antigen-detecting rapid diagnostic tests (Ag-RDTs), self-testing is a feasible option. - Objective - The goal of this study was a head-to-head comparison of diagnostic accuracy of patient sel...

Full description

Saved in:
Bibliographic Details
Main Authors: Lindner, Andreas (Author) , Nikolai, Olga (Author) , Rohardt, Chiara (Author) , Kausch, Franka (Author) , Wintel, Mia (Author) , Gertler, Maximilian (Author) , Burock, Susen (Author) , Hörig, Merle (Author) , Bernhard, Julian (Author) , Tobian, Frank (Author) , Gaeddert, Mary (Author) , Lainati, Federica (Author) , Corman, Victor M. (Author) , Jones, Terry C. (Author) , Sacks, Jilian A. (Author) , Seybold, Joachim (Author) , Denkinger, Claudia M. (Author) , Mockenhaupt, Frank P. (Author)
Format: Article (Journal)
Language:English
Published: 29 May 2021
In: Clinical and diagnostic virology
Year: 2021, Volume: 141, Pages: 1-4
ISSN:1873-4901
DOI:10.1016/j.jcv.2021.104874
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jcv.2021.104874
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1386653221001414
Get full text
Author Notes:Andreas K. Lindner, Olga Nikolai, Chiara Rohardt, Franka Kausch, Mia Wintel, Maximilian Gertler, Susen Burock, Merle Hörig, Julian Bernhard, Frank Tobian, Mary Gaeddert, Federica Lainati, Victor M. Corman, Terry C. Jones, Jilian A. Sacks, Joachim Seybold, Claudia M. Denkinger, Frank P. Mockenhaupt

MARC

LEADER 00000caa a2200000 c 4500
001 177281721X
003 DE-627
005 20230426091831.0
007 cr uuu---uuuuu
008 211008s2021 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.jcv.2021.104874  |2 doi 
035 |a (DE-627)177281721X 
035 |a (DE-599)KXP177281721X 
035 |a (OCoLC)1341421745 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Lindner, Andreas  |d 1975-  |e VerfasserIn  |0 (DE-588)133346528  |0 (DE-627)54365026X  |0 (DE-576)299786447  |4 aut 
245 1 0 |a Diagnostic accuracy and feasibility of patient self-testing with a SARS-CoV-2 antigen-detecting rapid test  |c Andreas K. Lindner, Olga Nikolai, Chiara Rohardt, Franka Kausch, Mia Wintel, Maximilian Gertler, Susen Burock, Merle Hörig, Julian Bernhard, Frank Tobian, Mary Gaeddert, Federica Lainati, Victor M. Corman, Terry C. Jones, Jilian A. Sacks, Joachim Seybold, Claudia M. Denkinger, Frank P. Mockenhaupt 
264 1 |c 29 May 2021 
300 |a 4 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 08.10.2021 
520 |a Background - Considering the possibility of nasal self-sampling and the ease of use in performing SARS-CoV-2 antigen-detecting rapid diagnostic tests (Ag-RDTs), self-testing is a feasible option. - Objective - The goal of this study was a head-to-head comparison of diagnostic accuracy of patient self-testing with professional testing using a SARS-CoV-2 Ag-RDT. - Study design - We performed a manufacturer-independent, prospective diagnostic accuracy study of nasal mid-turbinate self-sampling and self-testing with symptomatic adults using a WHO-listed SARS-CoV-2 Ag-RDT. Procedures were observed without intervention. For comparison, Ag-RDTs with nasopharyngeal sampling were professionally performed. Estimates of agreement, sensitivity, and specificity relative to RT-PCR on a combined oro-/nasopharyngeal sample were calculated. Feasibility was evaluated by observer and participant questionnaires. - Results - Among 146 symptomatic adults, 40 (27.4%) were RT-PCR-positive for SARS-CoV-2. Sensitivity with self-testing was 82.5% (33/40; 95% CI 68.1-91.3), and 85.0% (34/40; 95% CI 70.9-92.9) with professional testing. At high viral load (≥7.0 log10 SARS-CoV-2 RNA copies/ml), sensitivity was 96.6% (28/29; 95% CI 82.8-99.8) for both self- and professional testing. Deviations in sampling and testing were observed in 25 out of the 40 PCR-positives. Most participants (80.9%) considered the Ag-RDT as easy to perform. - Conclusion - Laypersons suspected for SARS-CoV-2 infection were able to reliably perform the Ag-RDT and test themselves. Procedural errors might be reduced by refinement of the instructions for use or the product design/procedures. Self-testing allows more wide-spread and frequent testing. Paired with the appropriate information of the public about the benefits and risks, self-testing may have significant impact on the pandemic. 
650 4 |a Antigen-detecting rapid diagnostic test 
650 4 |a COVID-19 
650 4 |a SARS-CoV-2 
650 4 |a Self-swab 
650 4 |a Self-testing 
700 1 |a Nikolai, Olga  |e VerfasserIn  |4 aut 
700 1 |a Rohardt, Chiara  |e VerfasserIn  |4 aut 
700 1 |a Kausch, Franka  |e VerfasserIn  |4 aut 
700 1 |a Wintel, Mia  |e VerfasserIn  |4 aut 
700 1 |a Gertler, Maximilian  |e VerfasserIn  |4 aut 
700 1 |a Burock, Susen  |e VerfasserIn  |4 aut 
700 1 |a Hörig, Merle  |e VerfasserIn  |4 aut 
700 1 |a Bernhard, Julian  |e VerfasserIn  |4 aut 
700 1 |a Tobian, Frank  |e VerfasserIn  |0 (DE-588)1208213326  |0 (DE-627)1694423093  |4 aut 
700 1 |a Gaeddert, Mary  |e VerfasserIn  |0 (DE-588)1223468550  |0 (DE-627)1742829112  |4 aut 
700 1 |a Lainati, Federica  |e VerfasserIn  |0 (DE-588)1223468119  |0 (DE-627)1742827861  |4 aut 
700 1 |a Corman, Victor M.  |e VerfasserIn  |4 aut 
700 1 |a Jones, Terry C.  |e VerfasserIn  |4 aut 
700 1 |a Sacks, Jilian A.  |e VerfasserIn  |4 aut 
700 1 |a Seybold, Joachim  |e VerfasserIn  |4 aut 
700 1 |a Denkinger, Claudia M.  |d 1978-  |e VerfasserIn  |0 (DE-588)131597701  |0 (DE-627)511279469  |0 (DE-576)298613727  |4 aut 
700 1 |a Mockenhaupt, Frank P.  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Clinical and diagnostic virology  |d Amsterdam [u.a.] : Elsevier Science, 1993  |g 141(2021) vom: Aug., Artikel-ID 104874, Seite 1-4  |h Online-Ressource  |w (DE-627)306654539  |w (DE-600)1499932-8  |w (DE-576)121465446  |x 1873-4901  |7 nnas  |a Diagnostic accuracy and feasibility of patient self-testing with a SARS-CoV-2 antigen-detecting rapid test 
773 1 8 |g volume:141  |g year:2021  |g month:08  |g elocationid:104874  |g pages:1-4  |g extent:4  |a Diagnostic accuracy and feasibility of patient self-testing with a SARS-CoV-2 antigen-detecting rapid test 
856 4 0 |u https://doi.org/10.1016/j.jcv.2021.104874  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S1386653221001414  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20211008 
993 |a Article 
994 |a 2021 
998 |g 131597701  |a Denkinger, Claudia M.  |m 131597701:Denkinger, Claudia M.  |d 910000  |d 911700  |d 50000  |e 910000PD131597701  |e 911700PD131597701  |e 50000PD131597701  |k 0/910000/  |k 1/910000/911700/  |k 0/50000/  |p 17 
998 |g 1223468119  |a Lainati, Federica  |m 1223468119:Lainati, Federica  |d 50000  |e 50000PL1223468119  |k 0/50000/  |p 12 
998 |g 1223468550  |a Gaeddert, Mary  |m 1223468550:Gaeddert, Mary  |d 910000  |d 911700  |e 910000PG1223468550  |e 911700PG1223468550  |k 0/910000/  |k 1/910000/911700/  |p 11 
998 |g 1208213326  |a Tobian, Frank  |m 1208213326:Tobian, Frank  |d 910000  |d 912800  |e 910000PT1208213326  |e 912800PT1208213326  |k 0/910000/  |k 1/910000/912800/  |p 10 
999 |a KXP-PPN177281721X  |e 3985470820 
BIB |a Y 
SER |a journal 
JSO |a {"name":{"displayForm":["Andreas K. Lindner, Olga Nikolai, Chiara Rohardt, Franka Kausch, Mia Wintel, Maximilian Gertler, Susen Burock, Merle Hörig, Julian Bernhard, Frank Tobian, Mary Gaeddert, Federica Lainati, Victor M. Corman, Terry C. Jones, Jilian A. Sacks, Joachim Seybold, Claudia M. Denkinger, Frank P. Mockenhaupt"]},"id":{"eki":["177281721X"],"doi":["10.1016/j.jcv.2021.104874"]},"relHost":[{"pubHistory":["1.1993/94 - 10.1998,2/3"],"origin":[{"publisher":"Elsevier Science","publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1993","dateIssuedDisp":"1993-1998"}],"note":["Gesehen am 14.02.24"],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"year":"2021","pages":"1-4","extent":"4","volume":"141","text":"141(2021) vom: Aug., Artikel-ID 104874, Seite 1-4"},"title":[{"title":"Clinical and diagnostic virology","title_sort":"Clinical and diagnostic virology"}],"id":{"zdb":["1499932-8"],"issn":["1873-4901"],"eki":["306654539"]},"physDesc":[{"extent":"Online-Ressource"}],"recId":"306654539","disp":"Diagnostic accuracy and feasibility of patient self-testing with a SARS-CoV-2 antigen-detecting rapid testClinical and diagnostic virology"}],"person":[{"role":"aut","given":"Andreas","family":"Lindner","display":"Lindner, Andreas"},{"display":"Nikolai, Olga","role":"aut","given":"Olga","family":"Nikolai"},{"display":"Rohardt, Chiara","family":"Rohardt","role":"aut","given":"Chiara"},{"role":"aut","given":"Franka","family":"Kausch","display":"Kausch, Franka"},{"given":"Mia","role":"aut","family":"Wintel","display":"Wintel, Mia"},{"display":"Gertler, Maximilian","role":"aut","given":"Maximilian","family":"Gertler"},{"family":"Burock","role":"aut","given":"Susen","display":"Burock, Susen"},{"family":"Hörig","role":"aut","given":"Merle","display":"Hörig, Merle"},{"display":"Bernhard, Julian","role":"aut","given":"Julian","family":"Bernhard"},{"display":"Tobian, Frank","given":"Frank","role":"aut","family":"Tobian"},{"display":"Gaeddert, Mary","family":"Gaeddert","role":"aut","given":"Mary"},{"display":"Lainati, Federica","family":"Lainati","given":"Federica","role":"aut"},{"given":"Victor M.","role":"aut","family":"Corman","display":"Corman, Victor M."},{"display":"Jones, Terry C.","family":"Jones","given":"Terry C.","role":"aut"},{"display":"Sacks, Jilian A.","given":"Jilian A.","role":"aut","family":"Sacks"},{"display":"Seybold, Joachim","family":"Seybold","role":"aut","given":"Joachim"},{"family":"Denkinger","given":"Claudia M.","role":"aut","display":"Denkinger, Claudia M."},{"display":"Mockenhaupt, Frank P.","family":"Mockenhaupt","given":"Frank P.","role":"aut"}],"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"29 May 2021"}],"title":[{"title":"Diagnostic accuracy and feasibility of patient self-testing with a SARS-CoV-2 antigen-detecting rapid test","title_sort":"Diagnostic accuracy and feasibility of patient self-testing with a SARS-CoV-2 antigen-detecting rapid test"}],"note":["Gesehen am 08.10.2021"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"recId":"177281721X","physDesc":[{"extent":"4 S."}]} 
SRT |a LINDNERANDDIAGNOSTIC2920 

Similar Items