The expression levels of Toll-like receptors after metallic particle and ion exposition in the synovium of a murine model
To date, the exact role of specific Toll-like receptors (TLRs) in regulating immune reactivity to metallic byproducts of orthopedic implants has not been fully clarified. In light of the situation, our objective in this investigation was to assess the expression levels of surface TLRs after metallic...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
7 August 2021
|
| In: |
Journal of Clinical Medicine
Year: 2021, Jahrgang: 10, Heft: 16, Pages: 1-14 |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10163489 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.3390/jcm10163489 Verlag: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.3390%2Fjcm10163489&DestApp=DOI&SrcAppSID=D2LojIfiDSePqaUiPSY&SrcJTitle=JOURNAL+OF+CLINICAL+MEDICINE&DestDOIRegistrantName=MDPI+AG 
|
| Verfasserangaben: | Xiangyun Cheng, Volkmar Jansson, Jan Philippe Kretzer, Rainer Bader, Sandra Utzschneider and Alexander C. Paulus |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1773290819 | ||
| 003 | DE-627 | ||
| 005 | 20230427161820.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 211011s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/jcm10163489 |2 doi | |
| 035 | |a (DE-627)1773290819 | ||
| 035 | |a (DE-599)KXP1773290819 | ||
| 035 | |a (OCoLC)1341421897 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Cheng, Xiangyun |d 1990- |e VerfasserIn |0 (DE-588)1223559971 |0 (DE-627)1743014597 |4 aut | |
| 245 | 1 | 4 | |a The expression levels of Toll-like receptors after metallic particle and ion exposition in the synovium of a murine model |c Xiangyun Cheng, Volkmar Jansson, Jan Philippe Kretzer, Rainer Bader, Sandra Utzschneider and Alexander C. Paulus |
| 264 | 1 | |c 7 August 2021 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.10.2021 | ||
| 520 | |a To date, the exact role of specific Toll-like receptors (TLRs) in regulating immune reactivity to metallic byproducts of orthopedic implants has not been fully clarified. In light of the situation, our objective in this investigation was to assess the expression levels of surface TLRs after metallic particle and ion exposure in an established animal model. Ten female BALB/c mice in each group received intra-articular injections of phosphate buffer (PBS) (control), metallic particles (MP), and metallic ions (MI), respectively. Seven days later, immunohistochemical staining was undertaken in the synovial layer of the murine knee joints using anti-TLR 1, 2, 4, 5, and 6 polyclonal antibodies. In addition to increased cellular infiltrates and a hyperplastic synovial membrane, the MP group showed significantly elevated TLR expression compared to the control group and had higher TLR 1-, 4-, and 6-positive cells than the MI group (p < 0.0167). TLR 4- and TLR 6-positive cells were significantly augmented for the MI group compared to the control group (p < 0.0167). Additionally, greenish corrosion particles found in the necrotic tissue suggested that metallic particles might release a certain level of locally toxic metallic ions in vivo. | ||
| 650 | 4 | |a arthroplasty | |
| 650 | 4 | |a biological-activity | |
| 650 | 4 | |a corrosion | |
| 650 | 4 | |a danger | |
| 650 | 4 | |a hip | |
| 650 | 4 | |a immunity | |
| 650 | 4 | |a in-vivo | |
| 650 | 4 | |a inflammatory response | |
| 650 | 4 | |a inflammatory responses | |
| 650 | 4 | |a innate | |
| 650 | 4 | |a metallic ions | |
| 650 | 4 | |a metallic particles | |
| 650 | 4 | |a replacement | |
| 650 | 4 | |a synovium | |
| 650 | 4 | |a tlr | |
| 650 | 4 | |a wear particles | |
| 700 | 1 | |a Jansson, Volkmar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kretzer, Jan Philippe |d 1978- |e VerfasserIn |0 (DE-588)136998348 |0 (DE-627)589003690 |0 (DE-576)301383103 |4 aut | |
| 700 | 1 | |a Bader, Rainer |e VerfasserIn |4 aut | |
| 700 | 1 | |a Utzschneider, Sandra |e VerfasserIn |4 aut | |
| 700 | 1 | |a Paulus, Alexander C. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of Clinical Medicine |d Basel : MDPI, 2012 |g 10(2021), 16, Artikel-ID 3489, Seite 1-14 |h Online-Ressource |w (DE-627)718632478 |w (DE-600)2662592-1 |w (DE-576)365782718 |x 2077-0383 |7 nnas |a The expression levels of Toll-like receptors after metallic particle and ion exposition in the synovium of a murine model |
| 773 | 1 | 8 | |g volume:10 |g year:2021 |g number:16 |g elocationid:3489 |g pages:1-14 |g extent:14 |a The expression levels of Toll-like receptors after metallic particle and ion exposition in the synovium of a murine model |
| 856 | 4 | 0 | |u https://doi.org/10.3390/jcm10163489 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.3390%2Fjcm10163489&DestApp=DOI&SrcAppSID=D2LojIfiDSePqaUiPSY&SrcJTitle=JOURNAL+OF+CLINICAL+MEDICINE&DestDOIRegistrantName=MDPI+AG |x Verlag |
| 951 | |a AR | ||
| 992 | |a 20211011 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 136998348 |a Kretzer, Jan Philippe |m 136998348:Kretzer, Jan Philippe |d 910000 |d 911460 |d 50000 |e 910000PK136998348 |e 911460PK136998348 |e 50000PK136998348 |k 0/910000/ |k 1/910000/911460/ |k 0/50000/ |p 3 | ||
| 999 | |a KXP-PPN1773290819 |e 3987974583 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1773290819","name":{"displayForm":["Xiangyun Cheng, Volkmar Jansson, Jan Philippe Kretzer, Rainer Bader, Sandra Utzschneider and Alexander C. Paulus"]},"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"7 August 2021"}],"person":[{"role":"aut","family":"Cheng","display":"Cheng, Xiangyun","given":"Xiangyun"},{"family":"Jansson","display":"Jansson, Volkmar","given":"Volkmar","role":"aut"},{"given":"Jan Philippe","display":"Kretzer, Jan Philippe","family":"Kretzer","role":"aut"},{"family":"Bader","given":"Rainer","display":"Bader, Rainer","role":"aut"},{"role":"aut","family":"Utzschneider","given":"Sandra","display":"Utzschneider, Sandra"},{"role":"aut","family":"Paulus","given":"Alexander C.","display":"Paulus, Alexander C."}],"language":["eng"],"title":[{"title_sort":"expression levels of Toll-like receptors after metallic particle and ion exposition in the synovium of a murine model","title":"The expression levels of Toll-like receptors after metallic particle and ion exposition in the synovium of a murine model"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"eki":["1773290819"],"doi":["10.3390/jcm10163489"]},"physDesc":[{"extent":"14 S."}],"relHost":[{"id":{"eki":["718632478"],"issn":["2077-0383"],"zdb":["2662592-1"]},"part":{"pages":"1-14","year":"2021","volume":"10","text":"10(2021), 16, Artikel-ID 3489, Seite 1-14","issue":"16","extent":"14"},"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 12.06.20"],"origin":[{"dateIssuedDisp":"2012-","publisher":"MDPI","publisherPlace":"Basel","dateIssuedKey":"2012"}],"title":[{"title":"Journal of Clinical Medicine","title_sort":"Journal of Clinical Medicine","subtitle":"open access journal"}],"pubHistory":["1.2012 -"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"The expression levels of Toll-like receptors after metallic particle and ion exposition in the synovium of a murine modelJournal of Clinical Medicine","recId":"718632478","language":["eng"]}],"note":["Gesehen am 11.10.2021"]} | ||
| SRT | |a CHENGXIANGEXPRESSION7202 | ||