Cellular immune responses against the cancer-testis antigen SPAN-XB in healthy donors and patients with multiple myeloma
The cancer-testis antigen SPAN-XB has been recently identified in multiple myeloma (MM). In the present study, we identified and characterized for the first time a cytotoxic cellular immune response against SPAN-XB in healthy donors and patients with MM. Using two independent computer algorithms, tw...
Gespeichert in:
| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2008
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| In: |
Leukemia and lymphoma
Year: 2008, Jahrgang: 49, Heft: 4, Pages: 779-785 |
| ISSN: | 1029-2403 |
| DOI: | 10.1080/10428190801911688 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/10428190801911688
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| Verfasserangaben: | Christian Frank, Michael Hundemer, Anthony D. Ho, Hartmut Goldschmidt, Mathias Witzens-Harig |
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| 245 | 1 | 0 | |a Cellular immune responses against the cancer-testis antigen SPAN-XB in healthy donors and patients with multiple myeloma |c Christian Frank, Michael Hundemer, Anthony D. Ho, Hartmut Goldschmidt, Mathias Witzens-Harig |
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| 520 | |a The cancer-testis antigen SPAN-XB has been recently identified in multiple myeloma (MM). In the present study, we identified and characterized for the first time a cytotoxic cellular immune response against SPAN-XB in healthy donors and patients with MM. Using two independent computer algorithms, two SPAN-XB-derived peptides (peptides 624 and 626) with predicted binding to HLA-A2 were identified. To further improve the immunogenicity of peptide 626 we designed a heteroclitic peptide (peptide 627) by modifying one amino acid on the HLA binding position 2 of peptide 626. Using an IFN-γ Elispot assay we could demonstrate the presence and functional activity of CD8 peptide specific T cells with all tested peptides. By analysis of peripheral blood of 13 healthy donors and five patients with MM peptide specific T-cell precursors specifically recognizing at least one of the tested peptides could be detected and expanded in 9 of 13 of tested donors and 3 of 5 tested patients. Importantly, in two donors specific peptides could be generated against the heteroclitic peptide 627 but not against the native peptide 626. We conclude that SPAN-XB-derived peptides can elicit a consistent CD8 T cell response in healthy donors and patients with MM. | ||
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