Comparison of the composition of lymphocyte subpopulations in non-relapse and relapse patients with squamous cell carcinoma of the head and neck before, during radiochemotherapy and in the follow-up period: a multicenter prospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)

Radiochemotherapy (RCT) has been shown to induce changes in immune cell homeostasis which might affect antitumor immune responses. In the present study, we aimed to compare the composition and kinetics of major lymphocyte subsets in the periphery of patients with non-locoregional recurrent (n = 23)...

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Main Authors: Niu, Minli (Author) , Combs, Stephanie (Author) , Linge, Annett (Author) , Krause, Mechthild (Author) , Baumann, Michael (Author) , Lohaus, Fabian (Author) , Ebert, Nadja (Author) , Tinhofer, Ingeborg (Author) , Budach, Volker (Author) , Müller-von der Grün, Jens (Author) , Rödel, Franz (Author) , Grosu, Anca-Ligia (Author) , Multhoff, Gabriele (Author)
Format: Article (Journal)
Language:English
Published: 31 July 2021
In: Radiation oncology
Year: 2021, Volume: 16, Pages: 1-12
ISSN:1748-717X
DOI:10.1186/s13014-021-01868-5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13014-021-01868-5
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Author Notes:Minli Niu, Stephanie E. Combs, Annett Linge, Mechthild Krause, Michael Baumann, Fabian Lohaus, Nadja Ebert, Ingeborg Tinhofer, Volker Budach, Jens von der Grün, Franz Rödel, Anca-Ligia Grosu and Gabriele Multhoff
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Summary:Radiochemotherapy (RCT) has been shown to induce changes in immune cell homeostasis which might affect antitumor immune responses. In the present study, we aimed to compare the composition and kinetics of major lymphocyte subsets in the periphery of patients with non-locoregional recurrent (n = 23) and locoregional recurrent (n = 9) squamous cell carcinoma of the head and neck (SCCHN) upon primary RCT.
Item Description:Gesehen am 13.10.2021
Physical Description:Online Resource
ISSN:1748-717X
DOI:10.1186/s13014-021-01868-5