Dynamic patterns of global brain communication differentiate conscious from unconscious patients after severe brain injury
The neurophysiology of the subjective sensation of being conscious is elusive; therefore, it remains controversial how consciousness can be recognized in patients who are not responsive but seemingly awake. During general anesthesia, a model for the transition between consciousness and unconsciousne...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
09 September 2021
|
| In: |
Frontiers in systems neuroscience
Year: 2021, Jahrgang: 15, Pages: 1-9 |
| ISSN: | 1662-5137 |
| DOI: | 10.3389/fnsys.2021.625919 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fnsys.2021.625919 Verlag, kostenfrei, Volltext: https://www.frontiersin.org/article/10.3389/fnsys.2021.625919 
|
| Verfasserangaben: | Daniel Golkowski, Rebecca Willnecker, Jennifer Rösler, Andreas Ranft, Gerhard Schneider, Denis Jordan and Rüdiger Ilg |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 177466481X | ||
| 003 | DE-627 | ||
| 005 | 20220208212910.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 211021s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fnsys.2021.625919 |2 doi | |
| 035 | |a (DE-627)177466481X | ||
| 035 | |a (DE-599)KXP177466481X | ||
| 035 | |a (OCoLC)1295678703 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Golkowski, Daniel |d 1983- |e VerfasserIn |0 (DE-588)1026152402 |0 (DE-627)72619820X |0 (DE-576)37142500X |4 aut | |
| 245 | 1 | 0 | |a Dynamic patterns of global brain communication differentiate conscious from unconscious patients after severe brain injury |c Daniel Golkowski, Rebecca Willnecker, Jennifer Rösler, Andreas Ranft, Gerhard Schneider, Denis Jordan and Rüdiger Ilg |
| 264 | 1 | |c 09 September 2021 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.10.2021 | ||
| 520 | |a The neurophysiology of the subjective sensation of being conscious is elusive; therefore, it remains controversial how consciousness can be recognized in patients who are not responsive but seemingly awake. During general anesthesia, a model for the transition between consciousness and unconsciousness, specific covariance matrices between the activity of brain regions that we call patterns of global brain communication reliably disappear when people lose consciousness. This functional magnetic imaging study investigates how patterns of global brain communication relate to consciousness and unconsciousness in a heterogeneous sample during general anesthesia and after brain injury. First, we describe specific patterns of global brain communication during wakefulness that disappear during propofol (n = 11) and sevoflurane (n = 14) general anesthesia. Second, we search for these patterns in a cohort of unresponsive wakeful patients (n = 18) and unmatched healthy controls (n = 20) in order to evaluate their potential use in clinical practice. We found that patterns of global brain communication characterized by high covariance in sensory and motor areas or low overall covariance and their dynamic change were strictly associated with intact consciousness in this cohort. In addition, we show that the occurrence of these two patterns is significantly related to activity within the frontoparietal network of the brain, a network known to play a crucial role in conscious perception. We propose that this approach potentially recognizes consciousness in the clinical routine setting. | ||
| 700 | 1 | |a Willnecker, Rebecca |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rösler, Jennifer |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ranft, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schneider, Gerhard |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jordan, Denis |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ilg, Rüdiger |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in systems neuroscience |d Lausanne : Frontiers Research Foundation, 2007 |g 15(2021) vom: 9. Sept., Artikel-ID 625919, Seite 1-9 |h Online-Ressource |w (DE-627)579826740 |w (DE-600)2453005-0 |w (DE-576)286502348 |x 1662-5137 |7 nnas |a Dynamic patterns of global brain communication differentiate conscious from unconscious patients after severe brain injury |
| 773 | 1 | 8 | |g volume:15 |g year:2021 |g day:9 |g month:09 |g elocationid:625919 |g pages:1-9 |g extent:9 |a Dynamic patterns of global brain communication differentiate conscious from unconscious patients after severe brain injury |
| 856 | 4 | 0 | |u https://doi.org/10.3389/fnsys.2021.625919 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.frontiersin.org/article/10.3389/fnsys.2021.625919 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20211021 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 1026152402 |a Golkowski, Daniel |m 1026152402:Golkowski, Daniel |d 910000 |d 911100 |e 910000PG1026152402 |e 911100PG1026152402 |k 0/910000/ |k 1/910000/911100/ |p 1 |x j | ||
| 999 | |a KXP-PPN177466481X |e 3993365313 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"09 September 2021"}],"id":{"eki":["177466481X"],"doi":["10.3389/fnsys.2021.625919"]},"name":{"displayForm":["Daniel Golkowski, Rebecca Willnecker, Jennifer Rösler, Andreas Ranft, Gerhard Schneider, Denis Jordan and Rüdiger Ilg"]},"physDesc":[{"extent":"9 S."}],"relHost":[{"name":{"displayForm":["Frontiers Research Foundation"]},"id":{"zdb":["2453005-0"],"eki":["579826740"],"issn":["1662-5137"]},"origin":[{"dateIssuedDisp":"2007-","dateIssuedKey":"2007","publisher":"Frontiers Research Foundation","publisherPlace":"Lausanne"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Frontiers in systems neuroscience","title":"Frontiers in systems neuroscience"}],"recId":"579826740","language":["eng"],"disp":"Dynamic patterns of global brain communication differentiate conscious from unconscious patients after severe brain injuryFrontiers in systems neuroscience","note":["Gesehen am 08.04.14"],"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"pages":"1-9","year":"2021","extent":"9","text":"15(2021) vom: 9. Sept., Artikel-ID 625919, Seite 1-9","volume":"15"},"pubHistory":["2007 -"]}],"title":[{"title_sort":"Dynamic patterns of global brain communication differentiate conscious from unconscious patients after severe brain injury","title":"Dynamic patterns of global brain communication differentiate conscious from unconscious patients after severe brain injury"}],"person":[{"family":"Golkowski","given":"Daniel","display":"Golkowski, Daniel","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Willnecker, Rebecca","given":"Rebecca","family":"Willnecker"},{"family":"Rösler","given":"Jennifer","display":"Rösler, Jennifer","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"Ranft, Andreas","roleDisplay":"VerfasserIn","given":"Andreas","family":"Ranft"},{"family":"Schneider","given":"Gerhard","display":"Schneider, Gerhard","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Jordan, Denis","given":"Denis","family":"Jordan"},{"display":"Ilg, Rüdiger","roleDisplay":"VerfasserIn","role":"aut","family":"Ilg","given":"Rüdiger"}],"note":["Gesehen am 21.10.2021"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"recId":"177466481X"} | ||
| SRT | |a GOLKOWSKIDDYNAMICPAT0920 | ||