Advantages of plasmatic CXCL-10 as a prognostic and diagnostic biomarker for the risk of rejection and subclinical rejection in kidney transplantation
This study evaluate the potential of plasmatic CXCL-10 (pCXCL-10) as a pre&post transplantation prognostic and diagnostic biomarker of T-cell-mediated rejection (TCMR), antibody-mediated rejection (ABMR) and subclinical rejection (SCR) risk in adult kidney recipients considering BKV and CMV infe...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2 July 2021
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| In: |
Clinical immunology
Year: 2021, Jahrgang: 229, Pages: 1-12 |
| ISSN: | 1521-7035 |
| DOI: | 10.1016/j.clim.2021.108792 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.clim.2021.108792 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1521661621001297 
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| Verfasserangaben: | Olga Millán, Jordi Rovira, Lluis Guirado, Cristina Espinosa, Klemens Budde, Claudia Sommerer, Gaston J. Piñeiro, Fritz Diekmann, Mercè Brunet |
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| 245 | 1 | 0 | |a Advantages of plasmatic CXCL-10 as a prognostic and diagnostic biomarker for the risk of rejection and subclinical rejection in kidney transplantation |c Olga Millán, Jordi Rovira, Lluis Guirado, Cristina Espinosa, Klemens Budde, Claudia Sommerer, Gaston J. Piñeiro, Fritz Diekmann, Mercè Brunet |
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| 520 | |a This study evaluate the potential of plasmatic CXCL-10 (pCXCL-10) as a pre&post transplantation prognostic and diagnostic biomarker of T-cell-mediated rejection (TCMR), antibody-mediated rejection (ABMR) and subclinical rejection (SCR) risk in adult kidney recipients considering BKV and CMV infections as possible clinical confounder factors. Twenty-eight of 100 patients included experienced rejection (TCMR:14; ABMR:14); 8 SCR; 13 and 16 were diagnosed with BKV and CMV infection, respectively. Pre-transplantation pCXCL-10 was significantly increased in TCMR and ABMR and post-transplantation in TCMR, ABMR and SCR compared with nonrejectors. All CMV+ patients showed pCXCL-10 levels above the cutoff values established for rejection whereas the 80% of BKV+ patients showed pCXCL-10 concentration < 100 pg/mL. pCXCL-10 could improve pre-transplantation patient stratification and immunosuppressive treatment selection according to rejection risk; and after kidney transplantation could be a potential early prognostic biomarker for rejection. Clinical confounding factor in BKV+ and particularly in CMV+ patients must be discarded. | ||
| 650 | 4 | |a ABMR | |
| 650 | 4 | |a Biological matrix | |
| 650 | 4 | |a BKV | |
| 650 | 4 | |a CMV | |
| 650 | 4 | |a CXCL-10 | |
| 650 | 4 | |a Kidney transplantation | |
| 650 | 4 | |a Rejection (TCMR | |
| 650 | 4 | |a SCR) | |
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| 700 | 1 | |a Espinosa, Cristina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Budde, Klemens |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Piñeiro, Gaston J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Diekmann, Fritz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brunet, Mercè |e VerfasserIn |4 aut | |
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