The beauty of asymmetry: asymmetric divisions and self-renewal in the haematopoietic system
Purpose of review - The hallmark of stem cells is their dual abilities to self-renew and to differentiate into multiple lineages. To fulfill these functions they must undergo asymmetric division. A central question in developmental biology is how can a single cell divide to produce two progeny cell...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[2007]
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| In: |
Current opinion in hematology
Year: 2007, Jahrgang: 14, Heft: 4, Pages: 330-336 |
| ISSN: | 1531-7048 |
| DOI: | 10.1097/MOH.0b013e3281900f12 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/MOH.0b013e3281900f12 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/co-hematology/Fulltext/2007/07000/The_beauty_of_asymmetry__asymmetric_divisions_and.5.aspx 
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| Verfasserangaben: | Anthony D. Ho and Wolfgang Wagner |
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| 520 | |a Purpose of review - The hallmark of stem cells is their dual abilities to self-renew and to differentiate into multiple lineages. To fulfill these functions they must undergo asymmetric division. A central question in developmental biology is how can a single cell divide to produce two progeny cells that adopt different fates? We provided evidence of the significance of asymmetric division in human haematopoietic stem cells. - Recent findings - By monitoring the symmetry of divisions of haematopoietic stem cells and following their subsequent developmental potentials at the single cell level, we established a relationship between divisional kinetics and self-renewal capacity. Direct cell-cell contact with cellular determinants in the niche has been shown to play an essential role in maintaining stemness. The creation of in-vitro models for the niche, such as human mesenchymal stromal cells, has provided a controlled laboratory environment in which the relative significance of chemokines and adhesion molecules can be studied. - Summary - Identification of the molecular interactions between stem cells and their niche has led to an understanding of the mechanisms that control the self-renewal of stem cells. Ultimately, molecular signals triggered by adhesion and junction complexes are responsible for the adoption of specific cell fate. | ||
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