Effect of CD34+ cell dose on hematopoietic reconstitution and outcome in 508 patients with multiple myeloma undergoing autologous peripheral blood stem cell transplantation
Background: We analyzed the hematopoietic reconstitution and outcome of 508 patients with multiple myeloma (MM) with respect to the number of CD34+ cells reinfused at our center. Patients and methods: Each cohort of 390 patients (unselected CD34+ cell transplant) and 118 patients (CD34+ selected tra...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[January 2007]
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| In: |
European journal of haematology
Year: 2007, Jahrgang: 78, Heft: 1, Pages: 21-28 |
| ISSN: | 1600-0609 |
| DOI: | 10.1111/j.0902-4441.2006.t01-1-EJH2895.x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.0902-4441.2006.t01-1-EJH2895.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.0902-4441.2006.t01-1-EJH2895.x 
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| Verfasserangaben: | Jens Klaus, Doris Herrmann, Iris Breitkreutz, Ute Hegenbart, Uta Mazitschek, Gerlinde Egerer, Friedrich W. Cremer, Ray M. Lowenthal, Johannes Huesing, Stefan Fruehauf, Thomas Moehler, Anthony D. Ho, Hartmut Goldschmidt |
MARC
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| 245 | 1 | 0 | |a Effect of CD34+ cell dose on hematopoietic reconstitution and outcome in 508 patients with multiple myeloma undergoing autologous peripheral blood stem cell transplantation |c Jens Klaus, Doris Herrmann, Iris Breitkreutz, Ute Hegenbart, Uta Mazitschek, Gerlinde Egerer, Friedrich W. Cremer, Ray M. Lowenthal, Johannes Huesing, Stefan Fruehauf, Thomas Moehler, Anthony D. Ho, Hartmut Goldschmidt |
| 246 | 3 | 3 | |a Effect of CD34 + cell dose on hematopoietic reconstitution and outcome in 508 patients with multiple myeloma undergoing autologous peripheral blood stem cell transplantation |
| 264 | 1 | |c [January 2007] | |
| 264 | 4 | |c © 2006 | |
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| 520 | |a Background: We analyzed the hematopoietic reconstitution and outcome of 508 patients with multiple myeloma (MM) with respect to the number of CD34+ cells reinfused at our center. Patients and methods: Each cohort of 390 patients (unselected CD34+ cell transplant) and 118 patients (CD34+ selected transplant) was divided into four subgroups. Among the 390 transplantations, 86 patients received a high dose (HD−) of ≥6.50 × 106 unselected CD34+ cells/kg, 116 patients a low dose (LD−) of <3.00 × 106 CD34+ cells/kg. Among the patients treated with CD34+ selected PBSC, 34 received ≥6.50 × 106 CD34+ cells/kg (HD+) and 16 <3.00 × 106 CD34+ cells/kg (LD+). Results: HD− patients experienced a reduced median time to leukocyte (13 d vs. 14 d) (P < 0.001) and platelet reconstitution >20 × 109/L (10 d vs. 12 d) (P < 0.001). Similarly, HD+ showed a reduced median time to leukocyte (12 d vs. 15 d) (P < 0.001) and platelet recovery >20 × 109/L (10 d vs. 11 d) (P = 0.058). CD34+ cell-dose was significant for long-term platelet recovery at day 360 (unselected transplant P = 0.015, selected transplant P = 0.023). Number of transplanted CD34+ cells had no significant impact on transplant related mortality, overall survival or CR/PR rates within 100 d. In terms of supportive care the differences of high-/low-dose grafts were minimal. Conclusions: These results confirm that high doses of CD34+ PBSC shorten hematopoietic reconstitution and reduce hospitalization. Nevertheless secure engraftment results from transplantation of 2.00-3.00 × 106 CD34+ cells/kg. As 60% of our pretreated patients are able to collect ≥5.00 × 106 CD34+ cells/kg within a single leukapheresis, division into two or more freezing bags allows safe tandem transplantation in the majority of MM patients. | ||
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| 650 | 4 | |a hematopoietic reconstitution | |
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