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Intravenous delivery of autologous mesenchymal stem cells limits infarct size and improves left ventricular function in the infarcted porcine heart

Systemic delivery of bone marrow-derived mesenchymal stem cells (MSCs) is a noninvasive approach for myocardial repair. We aimed to test this strategy in a pig model of myocardial infarction. Pigs (n = 8) received autologous MSCs (1 x 106/kg body weight) labeled with fluorescent dye 48 h post proxim...

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Main Authors: Krause, Ulf (Author) , Harter, Christoph (Author) , Seckinger, Anja (Author) , Wolf, David Gregor (Author) , Reinhardt, Adrian (Author) , Bea, Florian (Author) , Dengler, Thomas (Author) , Hardt, Stefan (Author) , Ho, Anthony Dick (Author) , Katus, Hugo (Author) , Kücherer, Helmut (Author) , Hansen, Alexander E. W. (Author)
Format: Article (Journal)
Language:English
Published: 11 Mar 2007
In: Stem Cells and Development
Year: 2007, Volume: 16, Issue: 1, Pages: 31-38
ISSN:1557-8534
DOI:10.1089/scd.2006.0089
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1089/scd.2006.0089
Verlag, lizenzpflichtig, Volltext: https://www.liebertpub.com/doi/10.1089/scd.2006.0089
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Author Notes:Ulf Krause, Christoph Harter, Anja Seckinger, David Wolf, Adrian Reinhard, Florian Bea, Thomas Dengler, Stefan Hardt, Anthony Ho, Hugo A. Katus, Helmut Kuecherer, and Alexander Hansen
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Summary:Systemic delivery of bone marrow-derived mesenchymal stem cells (MSCs) is a noninvasive approach for myocardial repair. We aimed to test this strategy in a pig model of myocardial infarction. Pigs (n = 8) received autologous MSCs (1 x 106/kg body weight) labeled with fluorescent dye 48 h post proximal left anterior descending artery (LAD) occlusion. Hemodyamics, infarct size, and myocardial function were assessed at baseline and after 1 month. Morphologic analysis revealed that labeled MSCs migrated in the peri-infarct region, resulting in smaller infarct size (32 ± 7 vs. 19 ± 7%, p = 0.01), higher fractional area shortening (23 ± 3 vs. 34.0 ± 7%, p = 0.001), lower left ventricular end diastolic pressure (18.7 ± 5 vs. 10.2 ± 4 mmHg, p = 0.02) and higher +dp/dt (4,570 ± 540 vs. 6,742 ± 700 mmHg/s, p = 0.03) during inotropic stimulation. Systemic intravenous delivery of MSCs to pigs limits myocardial infarct size and is an attractive approach for tissue repair.
Item Description:Gesehen am 26.10.2021
Physical Description:Online Resource
ISSN:1557-8534
DOI:10.1089/scd.2006.0089

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