Prediction of combination therapies based on topological modeling of the immune signaling network in multiple sclerosis

Multiple sclerosis (MS) is a major health problem, leading to a significant disability and patient suffering. Although chronic activation of the immune system is a hallmark of the disease, its pathogenesis is poorly understood, while current treatments only ameliorate the disease and may produce sev...

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Hauptverfasser: Bernardo Faura, Martí (VerfasserIn) , Rinas, Melanie (VerfasserIn) , Wirbel, Jakob (VerfasserIn) , Pertsovskaya, Inna (VerfasserIn) , Pliaka, Vicky (VerfasserIn) , Messinis, Dimitris E. (VerfasserIn) , Vila, Gemma (VerfasserIn) , Sakellaropoulos, Theodore (VerfasserIn) , Faigle, Wolfgang (VerfasserIn) , Stridh, Pernilla (VerfasserIn) , Behrens, Janina R. (VerfasserIn) , Olsson, Tomas (VerfasserIn) , Martin, Roland (VerfasserIn) , Paul, Friedemann (VerfasserIn) , Alexopoulos, Leonidas G. (VerfasserIn) , Villoslada, Pablo (VerfasserIn) , Sáez Rodríguez, Julio (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 16 July 2021
In: Genome medicine
Year: 2021, Jahrgang: 13, Pages: 1-16
ISSN:1756-994X
DOI:10.1186/s13073-021-00925-8
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13073-021-00925-8
Volltext
Verfasserangaben:Marti Bernardo-Faura, Melanie Rinas, Jakob Wirbel, Inna Pertsovskaya, Vicky Pliaka, Dimitris E. Messinis, Gemma Vila, Theodore Sakellaropoulos, Wolfgang Faigle, Pernilla Stridh, Janina R. Behrens, Tomas Olsson, Roland Martin, Friedemann Paul, Leonidas G. Alexopoulos, Pablo Villoslada and Julio Saez-Rodriguez
Beschreibung
Zusammenfassung:Multiple sclerosis (MS) is a major health problem, leading to a significant disability and patient suffering. Although chronic activation of the immune system is a hallmark of the disease, its pathogenesis is poorly understood, while current treatments only ameliorate the disease and may produce severe side effects.
Beschreibung:Gesehen am 28.10.2021
Beschreibung:Online Resource
ISSN:1756-994X
DOI:10.1186/s13073-021-00925-8