Richness of human gut microbiome correlates with metabolic markers
We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut...
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| Weitere Verfasser: | , |
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 August 2013
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| In: |
Nature
Year: 2013, Jahrgang: 500, Heft: 7464, Pages: 541-546 |
| ISSN: | 1476-4687 |
| DOI: | 10.1038/nature12506 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nature12506 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nature12506 
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| Verfasserangaben: | Emmanuelle Le Chatelier, Trine Nielsen, Junjie Qin, Edi Prifti, Falk Hildebrand, Gwen Falony, Mathieu Almeida, Manimozhiyan Arumugam, Jean-Michel Batto, Sean Kennedy, Pierre Leonard, Junhua Li, Kristoffer Burgdorf, Niels Grarup, Torben Jørgensen, Ivan Brandslund, Henrik Bjørn Nielsen, Agnieszka S. Juncker, Marcelo Bertalan, Florence Levenez, Nicolas Pons, Simon Rasmussen, Shinichi Sunagawa, Julien Tap, Sebastian Tims, Erwin G. Zoetendal, Søren Brunak, Karine Clément, Joël Doré, Michiel Kleerebezem, Karsten Kristiansen, Pierre Renault, Thomas Sicheritz-Ponten, Willem M. de Vos, Jean-Daniel Zucker, Jeroen Raes, Torben Hansen, MetaHIT consortium, Peer Bork, Jun Wang, S. Dusko Ehrlich & Oluf Pedersen ; MetaHIT consortium additional members: Eric Guedon, Takuji Yamada ... [und 39 andere] |
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| 245 | 1 | 0 | |a Richness of human gut microbiome correlates with metabolic markers |c Emmanuelle Le Chatelier, Trine Nielsen, Junjie Qin, Edi Prifti, Falk Hildebrand, Gwen Falony, Mathieu Almeida, Manimozhiyan Arumugam, Jean-Michel Batto, Sean Kennedy, Pierre Leonard, Junhua Li, Kristoffer Burgdorf, Niels Grarup, Torben Jørgensen, Ivan Brandslund, Henrik Bjørn Nielsen, Agnieszka S. Juncker, Marcelo Bertalan, Florence Levenez, Nicolas Pons, Simon Rasmussen, Shinichi Sunagawa, Julien Tap, Sebastian Tims, Erwin G. Zoetendal, Søren Brunak, Karine Clément, Joël Doré, Michiel Kleerebezem, Karsten Kristiansen, Pierre Renault, Thomas Sicheritz-Ponten, Willem M. de Vos, Jean-Daniel Zucker, Jeroen Raes, Torben Hansen, MetaHIT consortium, Peer Bork, Jun Wang, S. Dusko Ehrlich & Oluf Pedersen ; MetaHIT consortium additional members: Eric Guedon, Takuji Yamada ... [und 39 andere] |
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| 520 | |a We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities. | ||
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