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Anti-apoptotic signature in thymic squamous cell carcinomas - functional relevance of anti-apoptotic BIRC3 expression in the thymic carcinoma cell line 1889c

The molecular pathogenesis of thymomas and thymic carcinomas (TCs) is poorly understood and results of adjuvant therapy are unsatisfactory in case of metastatic disease and tumor recurrence. For these clinical settings, novel therapeutic strategies are urgently needed. Recently, limited sequencing e...

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Main Authors: Huang, Bei (Author) , Belharazem, Djeda (Author) , Li, Li (Author) , Kneitz, Susanne (Author) , Schnabel, Philipp Albert (Author) , Rieker, Ralf Joachim (Author) , Körner, Daniel (Author) , Nix, Winnfried (Author) , Schalke, Berthold (Author) , Müller-Hermelink, Hans Konrad (Author) , Ott, German (Author) , Rosenwald, Andreas (Author) , Ströbel, Philipp (Author) , Marx, Alexander (Author)
Format: Article (Journal)
Language:English
Published: 31 December 2013
In: Frontiers in oncology
Year: 2013, Volume: 3, Pages: 1-9
ISSN:2234-943X
DOI:10.3389/fonc.2013.00316
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fonc.2013.00316
Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/article/10.3389/fonc.2013.00316
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Author Notes:Bei Huang, Djeda Belharazem, Li Li, Susanne Kneitz, Philipp Schnabel, Ralf Rieker, Daniel Körner, Winnfried Nix, Berthold Schalke, Hans Konrad Müller-Hermelink, German Ott, Andreas Rosenwald, Philipp Ströbel and Alexander Marx
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Summary:The molecular pathogenesis of thymomas and thymic carcinomas (TCs) is poorly understood and results of adjuvant therapy are unsatisfactory in case of metastatic disease and tumor recurrence. For these clinical settings, novel therapeutic strategies are urgently needed. Recently, limited sequencing efforts revealed that a broad spectrum of genes that play key roles in various common cancers are rarely affected in thymomas and TCs, suggesting that other oncogenic principles might be important. This made us re-analyze historic expression data obtained in a spectrum of thymomas and thymic squamous cell carcinomas (TSCCs) with a custom-made cDNA microarray. By cluster analysis, different anti-apoptotic signatures were detected in type B3 thymoma and TSCC, including overexpression of BIRC3 in TSCCs. This was confirmed by qRT-PCR in the original and an independent validation set of tumors. In contrast to several other cancer cell lines, the BIRC3-positive TSCC cell line, 1889c showed spontaneous apoptosis after BIRC3 knock-down. Targeting apoptosis genes is worth testing as therapeutic principle in TSCC.
Item Description:Gesehen am 02.11.2021
Physical Description:Online Resource
ISSN:2234-943X
DOI:10.3389/fonc.2013.00316

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