Imatinib combined with mitoxantrone/etoposide and cytarabine is an effective induction therapy for patients with chronic myeloid leukemia in myeloid blast crisis
BACKGROUND Despite advances in drug therapy and allogeneic stem cell transplantation (allo-SCT), the prognosis of patients with chronic myeloid leukemia (CML) in blast crisis remains poor. Imatinib has demonstrated synergistic effects in vitro with mitoxantrone, etoposide, and cytarabine. METHODS A...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
05 March 2007
|
| In: |
Cancer
Year: 2007, Jahrgang: 109, Heft: 8, Pages: 1543-1549 |
| ISSN: | 1097-0142 |
| DOI: | 10.1002/cncr.22535 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/cncr.22535 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.22535 
|
| Verfasserangaben: | Stefan Fruehauf, Julian Topaly, Eike C. Buss, Thomas Fischer, Oliver G. Ottmann, Bertold Emmerich, Martin C. Müller, Peter Schuld, Leopold Balleisen, Rüdiger Hehlmann, Anthony D. Ho, Andreas Hochhaus |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 177586104X | ||
| 003 | DE-627 | ||
| 005 | 20230426125436.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 211102s2007 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/cncr.22535 |2 doi | |
| 035 | |a (DE-627)177586104X | ||
| 035 | |a (DE-599)KXP177586104X | ||
| 035 | |a (OCoLC)1341422102 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Frühauf, Stefan |d 1964- |e VerfasserIn |0 (DE-588)113078676 |0 (DE-627)618240306 |0 (DE-576)317921320 |4 aut | |
| 245 | 1 | 0 | |a Imatinib combined with mitoxantrone/etoposide and cytarabine is an effective induction therapy for patients with chronic myeloid leukemia in myeloid blast crisis |c Stefan Fruehauf, Julian Topaly, Eike C. Buss, Thomas Fischer, Oliver G. Ottmann, Bertold Emmerich, Martin C. Müller, Peter Schuld, Leopold Balleisen, Rüdiger Hehlmann, Anthony D. Ho, Andreas Hochhaus |
| 264 | 1 | |c 05 March 2007 | |
| 300 | |b Diagramme | ||
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 02.11.2021 | ||
| 520 | |a BACKGROUND Despite advances in drug therapy and allogeneic stem cell transplantation (allo-SCT), the prognosis of patients with chronic myeloid leukemia (CML) in blast crisis remains poor. Imatinib has demonstrated synergistic effects in vitro with mitoxantrone, etoposide, and cytarabine. METHODS A Phase I/II trial was performed in patients with CML myeloid blast crisis. Patients were treated with imatinib + mitoxantrone/etoposide in four cohorts: mitoxantrone 10 mg/m2/day and etoposide 100 mg/m2/day for 2 or 3 consecutive days and imatinib 600 mg/day from Day 15 (cohorts 1 and 2) or from Day 1 (cohorts 3 and 4). After hematologic reconstitution after the cytopenic phase, cytarabine was given at a dose of 10 mg/m2/day in addition to imatinib as maintenance treatment. RESULTS A total of 16 patients were available for analysis, median age 59 years (range, 37-74). All patients who received more intensive induction treatment (cohorts 3 and 4, n = 7) achieved a hematologic response (HR). In contrast, HR was achieved in only 6 of 9 patients treated in cohorts 1 and 2. The induction treatment was well tolerated. Six patients who achieved HR received an allo-SCT with myeloablative conditioning. The median survival in the transplant group was 16.2 months vs 4.7 months in the group with conventional treatment only (P = .067). CONCLUSIONS The combination of mitoxantrone/etoposide and imatinib is well tolerated, with mild nonhematologic toxicity even in older patients. Eligible patients benefit from allo-SCT after response to the induction treatment. Cancer 2007. © 2007 American Cancer Society. | ||
| 650 | 4 | |a allogeneic transplantation | |
| 650 | 4 | |a chemotherapy | |
| 650 | 4 | |a CML | |
| 650 | 4 | |a imatinib | |
| 650 | 4 | |a myeloid blast crisis | |
| 700 | 1 | |a Topaly, Julian |d 1973- |e VerfasserIn |0 (DE-588)124381383 |0 (DE-627)363308237 |0 (DE-576)294146563 |4 aut | |
| 700 | 1 | |a Buß, Eike Christian |d 1974- |e VerfasserIn |0 (DE-588)128723696 |0 (DE-627)37867658X |0 (DE-576)297299654 |4 aut | |
| 700 | 1 | |a Fischer, Thomas |d 1958- |e VerfasserIn |0 (DE-588)1257794345 |0 (DE-627)1802480323 |4 aut | |
| 700 | 1 | |a Ottmann, Oliver G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Emmerich, Bertold |e VerfasserIn |4 aut | |
| 700 | 1 | |a Müller, Martin Christian |d 1972- |e VerfasserIn |0 (DE-588)121360296 |0 (DE-627)705409236 |0 (DE-576)181482819 |4 aut | |
| 700 | 1 | |a Schuld, Peter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Balleisen, Leopold |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hehlmann, Rüdiger |d 1941- |e VerfasserIn |0 (DE-588)1037003489 |0 (DE-627)751737879 |0 (DE-576)390939463 |4 aut | |
| 700 | 1 | |a Ho, Anthony Dick |d 1948- |e VerfasserIn |0 (DE-588)108692477 |0 (DE-627)504904205 |0 (DE-576)19010466X |4 aut | |
| 700 | 1 | |a Hochhaus, Andreas |d 1959- |e VerfasserIn |0 (DE-588)1107039339 |0 (DE-627)863321976 |0 (DE-576)474976130 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer |d New York, NY : Wiley-Liss, 1948 |g 109(2007), 8, Seite 1543-1549 |h Online-Ressource |w (DE-627)271350334 |w (DE-600)1479932-7 |w (DE-576)078590884 |x 1097-0142 |7 nnas |a Imatinib combined with mitoxantrone/etoposide and cytarabine is an effective induction therapy for patients with chronic myeloid leukemia in myeloid blast crisis |
| 773 | 1 | 8 | |g volume:109 |g year:2007 |g number:8 |g pages:1543-1549 |g extent:7 |a Imatinib combined with mitoxantrone/etoposide and cytarabine is an effective induction therapy for patients with chronic myeloid leukemia in myeloid blast crisis |
| 856 | 4 | 0 | |u https://doi.org/10.1002/cncr.22535 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.22535 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20211102 | ||
| 993 | |a Article | ||
| 994 | |a 2007 | ||
| 998 | |g 1107039339 |a Hochhaus, Andreas |m 1107039339:Hochhaus, Andreas |d 60000 |d 61200 |e 60000PH1107039339 |e 61200PH1107039339 |k 0/60000/ |k 1/60000/61200/ |p 12 |y j | ||
| 998 | |g 108692477 |a Ho, Anthony Dick |m 108692477:Ho, Anthony Dick |d 910000 |d 910100 |e 910000PH108692477 |e 910100PH108692477 |k 0/910000/ |k 1/910000/910100/ |p 11 | ||
| 998 | |g 1037003489 |a Hehlmann, Rüdiger |m 1037003489:Hehlmann, Rüdiger |d 60000 |d 61200 |e 60000PH1037003489 |e 61200PH1037003489 |k 0/60000/ |k 1/60000/61200/ |p 10 | ||
| 998 | |g 121360296 |a Müller, Martin Christian |m 121360296:Müller, Martin Christian |d 60000 |d 61200 |e 60000PM121360296 |e 61200PM121360296 |k 0/60000/ |k 1/60000/61200/ |p 7 | ||
| 998 | |g 128723696 |a Buß, Eike Christian |m 128723696:Buß, Eike Christian |d 910000 |d 910100 |e 910000PB128723696 |e 910100PB128723696 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 124381383 |a Topaly, Julian |m 124381383:Topaly, Julian |d 910000 |d 910100 |e 910000PT124381383 |e 910100PT124381383 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 113078676 |a Frühauf, Stefan |m 113078676:Frühauf, Stefan |d 50000 |e 50000PF113078676 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN177586104X |e 3998335382 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"person":[{"role":"aut","given":"Stefan","display":"Frühauf, Stefan","family":"Frühauf"},{"role":"aut","given":"Julian","display":"Topaly, Julian","family":"Topaly"},{"display":"Buß, Eike Christian","family":"Buß","given":"Eike Christian","role":"aut"},{"role":"aut","given":"Thomas","family":"Fischer","display":"Fischer, Thomas"},{"role":"aut","given":"Oliver G.","family":"Ottmann","display":"Ottmann, Oliver G."},{"display":"Emmerich, Bertold","family":"Emmerich","given":"Bertold","role":"aut"},{"role":"aut","given":"Martin Christian","family":"Müller","display":"Müller, Martin Christian"},{"family":"Schuld","display":"Schuld, Peter","given":"Peter","role":"aut"},{"role":"aut","given":"Leopold","family":"Balleisen","display":"Balleisen, Leopold"},{"given":"Rüdiger","role":"aut","display":"Hehlmann, Rüdiger","family":"Hehlmann"},{"display":"Ho, Anthony Dick","family":"Ho","role":"aut","given":"Anthony Dick"},{"family":"Hochhaus","display":"Hochhaus, Andreas","given":"Andreas","role":"aut"}],"relHost":[{"id":{"eki":["271350334"],"doi":["10.1002/(ISSN)1097-0142"],"issn":["1097-0142"],"zdb":["1479932-7"]},"recId":"271350334","physDesc":[{"extent":"Online-Ressource"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Imatinib combined with mitoxantrone/etoposide and cytarabine is an effective induction therapy for patients with chronic myeloid leukemia in myeloid blast crisisCancer","note":["Gesehen am 06.12.2011"],"pubHistory":["1.1948 -"],"origin":[{"publisherPlace":"New York, NY","dateIssuedDisp":"1948-","dateIssuedKey":"1948","publisher":"Wiley-Liss"}],"title":[{"title":"Cancer","title_sort":"Cancer","subtitle":"interdisciplinary international journal of the American Cancer Society"}],"part":{"extent":"7","volume":"109","text":"109(2007), 8, Seite 1543-1549","issue":"8","year":"2007","pages":"1543-1549"},"titleAlt":[{"title":"Cancer cytopathology"}],"language":["eng"]}],"recId":"177586104X","physDesc":[{"noteIll":"Diagramme","extent":"7 S."}],"name":{"displayForm":["Stefan Fruehauf, Julian Topaly, Eike C. Buss, Thomas Fischer, Oliver G. Ottmann, Bertold Emmerich, Martin C. Müller, Peter Schuld, Leopold Balleisen, Rüdiger Hehlmann, Anthony D. Ho, Andreas Hochhaus"]},"id":{"doi":["10.1002/cncr.22535"],"eki":["177586104X"]},"title":[{"title":"Imatinib combined with mitoxantrone/etoposide and cytarabine is an effective induction therapy for patients with chronic myeloid leukemia in myeloid blast crisis","title_sort":"Imatinib combined with mitoxantrone/etoposide and cytarabine is an effective induction therapy for patients with chronic myeloid leukemia in myeloid blast crisis"}],"origin":[{"dateIssuedDisp":"05 March 2007","dateIssuedKey":"2007"}],"note":["Gesehen am 02.11.2021"],"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a FRUEHAUFSTIMATINIBCO0520 | ||