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Lumbar bone marrow microcirculation measurements from dynamic contrast-enhanced magnetic resonance imaging is a predictor of event-free survival in progressive multiple myeloma

Purpose: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with high temporal resolution enables the detection of microcirculation variables amplitude A and exchange rate constant kep. In this study, the prognostic value of the DCE-MRI variables for overall survival and event-free survi...

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Hauptverfasser: Hillengaß, Jens (VerfasserIn) , Wasser, Klaus (VerfasserIn) , Delorme, Stefan (VerfasserIn) , Kießling, Fabian (VerfasserIn) , Zechmann, Christian (VerfasserIn) , Benner, Axel (VerfasserIn) , Kauczor, Hans-Ulrich (VerfasserIn) , Ho, Anthony Dick (VerfasserIn) , Goldschmidt, Hartmut (VerfasserIn) , Möhler, Thomas (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: [January 2007]
In: Clinical cancer research
Year: 2007, Jahrgang: 13, Heft: 2, Pages: 475-481
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-06-0061
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/1078-0432.CCR-06-0061
Verlag, lizenzpflichtig, Volltext: https://clincancerres.aacrjournals.org/content/13/2/475
Volltext
Verfasserangaben:Jens Hillengass, Klaus Wasser, Stefan Delorme, Fabian Kiessling, Christian Zechmann, Axel Benner, Hans-Ulrich Kauczor, Anthony D. Ho, Hartmut Goldschmidt, and Thomas M. Moehler
Beschreibung
Zusammenfassung:Purpose: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with high temporal resolution enables the detection of microcirculation variables amplitude A and exchange rate constant kep. In this study, the prognostic value of the DCE-MRI variables for overall survival and event-free survival in patients with progressive multiple myeloma was investigated. - Experimental Design: Between 1999 and 2001, 65 patients with progressive or relapse of multiple myeloma requiring therapy were investigated with DCE-MRI of the lumbar spine before start of therapy. The contrast uptake was quantified using a two-compartment model with the output variables amplitude A and exchange rate constant kep reflecting bone marrow microcirculation. The estimated median follow-up was 56 months. Event-free survival and overall survival were investigated for DCE-MRI variables and for established prognosis variables (β2-microglobulin, lactate dehydrogenase, albumin, and age). - Results: Using a multivariate Cox regression model, β2-microglobulin and amplitude A of DCE-MRI were identified as statistically significant prognostic variable of event-free survival with Ps of 0.01 and 0.02, respectively. A statistical correlation of DCE-MRI variables with overall survival could not be found. The multivariate analysis of β2-microglobulin, age, lactate dehydrogenase, and albumin revealed β2-microglobulin as statistically significant prognostic factor for overall survival in this group of patients (P < 0.001). - Conclusions: This analysis identifies contrast-enhanced DCE-MRI variable amplitude A reflecting increased bone marrow microcirculation and angiogenesis as a novel and possibly useful prognostic factor in patients with multiple myeloma. Prospective studies are currently done to further investigate this functional variable for prognosis and stratification of myeloma patients.
Beschreibung:Gesehen am 02.11.2021
Beschreibung:Online Resource
ISSN:1557-3265
DOI:10.1158/1078-0432.CCR-06-0061

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