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Automatic airway analysis on multidetector computed tomography in cystic fibrosis: correlation with pulmonary function testing

Purpose: To evaluate the fully automatic quantification of airway dimensions on chest multidetector computed tomography (MDCT) performed in cystic fibrosis (CF) patients. Airflow indices including predicted forced expiratory volume in 1 second (FEV1%) were used to study the impact on regional lung f...

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Main Authors: Wielpütz, Mark Oliver (Author) , Eichinger, Monika (Author) , Weinheimer, Oliver (Author) , Ley, Sebastian (Author) , Mall, Marcus A. (Author) , Wiebel, Matthias (Author) , Bischoff, Arved (Author) , Kauczor, Hans-Ulrich (Author) , Heußel, Claus Peter (Author) , Puderbach, Michael (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: Journal of thoracic imaging
Year: 2013, Volume: 28, Issue: 2, Pages: 104-113
ISSN:1536-0237
DOI:10.1097/RTI.0b013e3182765785
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/RTI.0b013e3182765785
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/thoracicimaging/Abstract/2013/03000/Automatic_Airway_Analysis_on_Multidetector.6.aspx
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Author Notes:Mark O. Wielpütz, Monika Eichinger, Oliver Weinheimer, Sebastian Ley, Marcus A. Mall, Matthias Wiebel, Arved Bischoff, Hans-Ulrich Kauczor, Claus P. Heussel, Michael Puderbach
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Summary:Purpose: To evaluate the fully automatic quantification of airway dimensions on chest multidetector computed tomography (MDCT) performed in cystic fibrosis (CF) patients. Airflow indices including predicted forced expiratory volume in 1 second (FEV1%) were used to study the impact on regional lung function. - Materials and Methods: MDCT data of patients with CF (14 children and 23 adults) and of control patients (11 children and 22 adults) were used to compute total diameter (TD), lumen area (LA), and wall thickness (WT) using dedicated software. Pulmonary function testing including FEV1% was performed in parallel and correlated with MDCT parameters in a generation-based analysis. - Results: TD was largely increased in CF patients (third-generation to fourth-generation airways in children, first to ninth in adults; P<0.05). LA remained unchanged, but WT was also larger in CF compared with controls (third generation to sixth generation in children, first to eleventh in adults; P<0.05). In adult CF patients significant negative correlations for TD, LA, and WT with FEV1% were found for intermediate airways (fifth to seventh generation; r=−0.7 to −0.9) but not in pediatric CF patients and controls. - Conclusions: Automatic airway analysis succeeded in quantifying specific pathologies such as airway dilatation and wall thickening in CF patients at different ages. Moreover, our results indicate a shift in main airflow resistance to intermediate airways in cases of chronic CF. The objective computational parameters TD, LA, and WT should be considered for assessment and follow-up of CF airway disease.
Item Description:Gesehen am 08.11.2021
Physical Description:Online Resource
ISSN:1536-0237
DOI:10.1097/RTI.0b013e3182765785

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