A bioorthogonal click chemistry toolbox for targeted synthesis of branched and well-defined protein-protein conjugates

Bioorthogonal chemistry holds great potential to generate difficult-to-access protein-protein conjugate architectures. Current applications are hampered by challenging protein expression systems, slow conjugation chemistry, use of undesirable catalysts, or often do not result in quantitative product...

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Bibliographic Details

Main Authors:	Baalmann, Mathis (Author) , Neises, Laura (Author) , Bitsch, Sebastian (Author) , Schneider, Hendrik (Author) , Deweid, Ludwig Lukas (Author) , Werther, Philipp (Author) , Ilkenhans, Nadja (Author) , Wolfring, Martin (Author) , Ziegler, Michael J. (Author) , Wilhelm, Jonas (Author) , Kolmar, Harald (Author) , Wombacher, Richard (Author)
Format:	Article (Journal)
Language:	English
Published:	2020
In:	Angewandte Chemie. International edition Year: 2020, Volume: 59, Issue: 31, Pages: 12885-12893
ISSN:	1521-3773
DOI:	10.1002/anie.201915079
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1002/anie.201915079 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201915079
Author Notes:	Mathis Baalmann, Laura Neises, Sebastian Bitsch, Hendrik Schneider, Lukas Deweid, Philipp Werther, Nadja Ilkenhans, Martin Wolfring, Michael J. Ziegler, Jonas Wilhelm, Harald Kolmar, and Richard Wombacher