Practical guidance for combination lipid-modifying therapy in high- and very-high-risk patients: a statement from a European Atherosclerosis Society Task Force
Background and aims - This European Atherosclerosis Society (EAS) Task Force provides practical guidance for combination therapy for elevated low-density lipoprotein cholesterol (LDL-C) and/or triglycerides (TG) in high-risk and very-high-risk patients. - Methods - Evidence-based review. - Results -...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 2021
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| In: |
Atherosclerosis
Year: 2021, Jahrgang: 325, Pages: 99-109 |
| ISSN: | 1879-1484 |
| DOI: | 10.1016/j.atherosclerosis.2021.03.039 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.atherosclerosis.2021.03.039 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0021915021001623 
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| Verfasserangaben: | Maurizio Averna, Maciej Banach, Eric Bruckert, Heinz Drexel, Michel Farnier, Dan Gaita, Paolo Magni, Winfried März, Luis Masana, Alberto Mello e Silva, Zeljko Reiner, Emilio Ros, Michal Vrablik, Alberto Zambon, Jose L. Zamorano, Jane K. Stock, Lale S. Tokgözoğlu, Alberico L. Catapano |
MARC
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| 245 | 1 | 0 | |a Practical guidance for combination lipid-modifying therapy in high- and very-high-risk patients |b a statement from a European Atherosclerosis Society Task Force |c Maurizio Averna, Maciej Banach, Eric Bruckert, Heinz Drexel, Michel Farnier, Dan Gaita, Paolo Magni, Winfried März, Luis Masana, Alberto Mello e Silva, Zeljko Reiner, Emilio Ros, Michal Vrablik, Alberto Zambon, Jose L. Zamorano, Jane K. Stock, Lale S. Tokgözoğlu, Alberico L. Catapano |
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| 520 | |a Background and aims - This European Atherosclerosis Society (EAS) Task Force provides practical guidance for combination therapy for elevated low-density lipoprotein cholesterol (LDL-C) and/or triglycerides (TG) in high-risk and very-high-risk patients. - Methods - Evidence-based review. - Results - Statin-ezetimibe combination treatment is the first choice for managing elevated LDL-C and should be given upfront in very-high-risk patients with high LDL-C unlikely to reach goal with a statin, and in primary prevention familial hypercholesterolaemia patients. A proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor may be added if LDL-C levels remain high. In high and very-high-risk patients with mild to moderately elevated TG levels (>2.3 and < 5.6 mmol/L [>200 and < 500 mg/dL) on a statin, treatment with either a fibrate or high-dose omega-3 fatty acids (icosapent ethyl) may be considered, weighing the benefit versus risks. Combination with fenofibrate may be considered for both macro- and microvascular benefits in patients with type 2 diabetes mellitus. - Conclusions - This guidance aims to improve real-world use of guideline-recommended combination lipid modifying treatment. | ||
| 650 | 4 | |a 2019 ESC/EAS Dyslipidaemia Guidelines | |
| 650 | 4 | |a Combination treatment | |
| 650 | 4 | |a High-risk | |
| 650 | 4 | |a LDL cholesterol | |
| 650 | 4 | |a Lipid goals | |
| 650 | 4 | |a Triglycerides | |
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