Cerebral changes and cerebrospinal fluid β-amyloid in Alzheimer's disease: a study with quantitative magnetic resonance imaging
Pathological and biochemical studies indicate that β-amyloid (βA4) deposition is a hallmark in the pathogenesis of Alzheimer's disease (AD).1-4 Neuroimaging studies demonstrate that the respective cerebral changes primarily strike the temporal lobe and the amygdala-hippocampus complex and may b...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 October 1997
|
| In: |
Molecular psychiatry
Year: 1997, Jahrgang: 2, Heft: 6, Pages: 505-507 |
| ISSN: | 1476-5578 |
| DOI: | 10.1038/sj.mp.4000313 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1038/sj.mp.4000313 Verlag: https://www.nature.com/articles/4000313 
|
| Verfasserangaben: | J. Schröder, J. Pantel, N. Ida, M. Essig, T. Hartmann, M.V. Knopp, L.R. Schad, R. Sandbrink, H. Sauer, C.L. Masters, K. Beyreuther |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1777521580 | ||
| 003 | DE-627 | ||
| 005 | 20230426124455.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 211116s1997 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/sj.mp.4000313 |2 doi | |
| 035 | |a (DE-627)1777521580 | ||
| 035 | |a (DE-599)KXP1777521580 | ||
| 035 | |a (OCoLC)1341423452 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schröder, Johannes |d 1957- |e VerfasserIn |0 (DE-588)138708517 |0 (DE-627)605263469 |0 (DE-576)308769848 |4 aut | |
| 245 | 1 | 0 | |a Cerebral changes and cerebrospinal fluid β-amyloid in Alzheimer's disease |b a study with quantitative magnetic resonance imaging |c J. Schröder, J. Pantel, N. Ida, M. Essig, T. Hartmann, M.V. Knopp, L.R. Schad, R. Sandbrink, H. Sauer, C.L. Masters, K. Beyreuther |
| 264 | 1 | |c 01 October 1997 | |
| 300 | |a 3 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 16.11.2021 | ||
| 520 | |a Pathological and biochemical studies indicate that β-amyloid (βA4) deposition is a hallmark in the pathogenesis of Alzheimer's disease (AD).1-4 Neuroimaging studies demonstrate that the respective cerebral changes primarily strike the temporal lobe and the amygdala-hippocampus complex and may be reliably assessed using quantitative magnetic resonance imaging (MRI).5,6 Therefore one may expect that reduced βA4-levels are significantly correlated with measures of the temporal lobe rather than global cerebral atrophy in AD patients. To test this hypothesis in a clinical study, cerebrospinal fluid concentrations of total β A4 and its major C-terminal variations β A4 1-40 and β A4 1-42 were compared with cerebral changes as assessed by quantitative magnetic resonance imaging (MRI). Significantly (P < 0.05) reduced β A4 1-40 and β A4 1-42 levels were found in the AD patients (17 female; six male; AD/NINCDS-ADRDA-criteria)7 in comparison to the patients with major depression (seven female; two male; DSM-III-R).8 Within the AD group, βA4 and β xA4 1-42 levels were significantly correlated with the volume of the temporal lobes (r = 0.46 and r = 0.48, respectively) but none of the other volumetric measures. These findings indicate that changes in cerebral β A4 levels contribute to temporal lobe atrophy in AD and support the possibility that βA4 is central to the etiology of AD. | ||
| 650 | 4 | |a Behavioral Sciences | |
| 650 | 4 | |a Biological Psychology | |
| 650 | 4 | |a general | |
| 650 | 4 | |a Medicine/Public Health | |
| 650 | 4 | |a Neurosciences | |
| 650 | 4 | |a Pharmacotherapy | |
| 650 | 4 | |a Psychiatry | |
| 700 | 1 | |a Pantel, Johannes |d 1963- |e VerfasserIn |0 (DE-588)113067526 |0 (DE-627)588317039 |0 (DE-576)301323305 |4 aut | |
| 700 | 1 | |a Ida, N. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Essig, Marco |e VerfasserIn |0 (DE-588)1048464490 |0 (DE-627)780470605 |0 (DE-576)172458595 |4 aut | |
| 700 | 1 | |a Hartmann, Tobias |e VerfasserIn |0 (DE-588)108240022X |0 (DE-627)84746007X |0 (DE-576)455405824 |4 aut | |
| 700 | 1 | |a Knopp, Michael V. |e VerfasserIn |0 (DE-588)1076637442 |0 (DE-627)835139344 |0 (DE-576)167521527 |4 aut | |
| 700 | 1 | |a Schad, Lothar R. |d 1956- |e VerfasserIn |0 (DE-588)1028817630 |0 (DE-627)731640241 |0 (DE-576)376271221 |4 aut | |
| 700 | 1 | |a Sandbrink, Rupert |e VerfasserIn |0 (DE-588)1082529796 |0 (DE-627)847583333 |0 (DE-576)45548595X |4 aut | |
| 700 | 1 | |a Sauer, H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Masters, C. L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Beyreuther, Konrad |d 1941- |e VerfasserIn |0 (DE-588)133652580 |0 (DE-627)550295852 |0 (DE-576)299999424 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Molecular psychiatry |d [London] : Springer Nature, 1997 |g 2(1997), 6, Seite 505-507 |h Online-Ressource |w (DE-627)308450108 |w (DE-600)1502531-7 |w (DE-576)111905222 |x 1476-5578 |7 nnas |a Cerebral changes and cerebrospinal fluid β-amyloid in Alzheimer's disease a study with quantitative magnetic resonance imaging |
| 773 | 1 | 8 | |g volume:2 |g year:1997 |g number:6 |g pages:505-507 |g extent:3 |a Cerebral changes and cerebrospinal fluid β-amyloid in Alzheimer's disease a study with quantitative magnetic resonance imaging |
| 856 | 4 | 0 | |u https://doi.org/10.1038/sj.mp.4000313 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/4000313 |x Verlag |
| 951 | |a AR | ||
| 992 | |a 20211116 | ||
| 994 | |a 1997 | ||
| 998 | |g 133652580 |a Beyreuther, Konrad |m 133652580:Beyreuther, Konrad |d 700000 |d 706000 |e 700000PB133652580 |e 706000PB133652580 |k 0/700000/ |k 1/700000/706000/ |p 11 |y j | ||
| 998 | |g 1082529796 |a Sandbrink, Rupert |m 1082529796:Sandbrink, Rupert |p 8 | ||
| 998 | |g 1028817630 |a Schad, Lothar R. |m 1028817630:Schad, Lothar R. |d 60000 |e 60000PS1028817630 |k 0/60000/ |p 7 | ||
| 998 | |g 1076637442 |a Knopp, Michael V. |m 1076637442:Knopp, Michael V. |d 50000 |e 50000PK1076637442 |k 0/50000/ |p 6 | ||
| 998 | |g 108240022X |a Hartmann, Tobias |m 108240022X:Hartmann, Tobias |d 700000 |d 706000 |e 700000PH108240022X |e 706000PH108240022X |k 0/700000/ |k 1/700000/706000/ |p 5 | ||
| 998 | |g 1048464490 |a Essig, Marco |m 1048464490:Essig, Marco |d 50000 |e 50000PE1048464490 |k 0/50000/ |p 4 | ||
| 998 | |g 113067526 |a Pantel, Johannes |m 113067526:Pantel, Johannes |d 910000 |d 910600 |e 910000PP113067526 |e 910600PP113067526 |k 0/910000/ |k 1/910000/910600/ |p 2 | ||
| 998 | |g 138708517 |a Schröder, Johannes |m 138708517:Schröder, Johannes |d 910000 |d 910600 |e 910000PS138708517 |e 910600PS138708517 |k 0/910000/ |k 1/910000/910600/ |p 1 |x j | ||
| 999 | |a KXP-PPN1777521580 |e 4002447499 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"role":"aut","given":"Johannes","family":"Schröder","display":"Schröder, Johannes"},{"role":"aut","given":"Johannes","display":"Pantel, Johannes","family":"Pantel"},{"role":"aut","given":"N.","display":"Ida, N.","family":"Ida"},{"family":"Essig","display":"Essig, Marco","given":"Marco","role":"aut"},{"role":"aut","given":"Tobias","display":"Hartmann, Tobias","family":"Hartmann"},{"role":"aut","given":"Michael V.","family":"Knopp","display":"Knopp, Michael V."},{"given":"Lothar R.","role":"aut","family":"Schad","display":"Schad, Lothar R."},{"role":"aut","given":"Rupert","family":"Sandbrink","display":"Sandbrink, Rupert"},{"display":"Sauer, H.","family":"Sauer","role":"aut","given":"H."},{"given":"C. L.","role":"aut","family":"Masters","display":"Masters, C. L."},{"family":"Beyreuther","display":"Beyreuther, Konrad","given":"Konrad","role":"aut"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title":"Cerebral changes and cerebrospinal fluid β-amyloid in Alzheimer's disease","title_sort":"Cerebral changes and cerebrospinal fluid β-amyloid in Alzheimer's disease","subtitle":"a study with quantitative magnetic resonance imaging"}],"origin":[{"dateIssuedKey":"1997","dateIssuedDisp":"01 October 1997"}],"note":["Gesehen am 16.11.2021"],"id":{"doi":["10.1038/sj.mp.4000313"],"eki":["1777521580"]},"physDesc":[{"extent":"3 S."}],"name":{"displayForm":["J. Schröder, J. Pantel, N. Ida, M. Essig, T. Hartmann, M.V. Knopp, L.R. Schad, R. Sandbrink, H. Sauer, C.L. Masters, K. Beyreuther"]},"relHost":[{"part":{"extent":"3","volume":"2","issue":"6","text":"2(1997), 6, Seite 505-507","pages":"505-507","year":"1997"},"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Cerebral changes and cerebrospinal fluid β-amyloid in Alzheimer's disease a study with quantitative magnetic resonance imagingMolecular psychiatry","title":[{"title":"Molecular psychiatry","title_sort":"Molecular psychiatry"}],"origin":[{"publisherPlace":"[London] ; London","dateIssuedDisp":"[1997?]-","publisher":"Springer Nature ; Macmillan"}],"note":["Gesehen am 13.06.24"],"pubHistory":["Nachgewiesen 2.1997 -"],"id":{"eki":["308450108"],"zdb":["1502531-7"],"issn":["1476-5578"]},"physDesc":[{"extent":"Online-Ressource"}],"recId":"308450108"}],"recId":"1777521580"} | ||
| SRT | |a SCHROEDERJCEREBRALCH0119 | ||