Einblicke in die Entstehung von Mikrotubuli: Cytoskelett
Microtubules are part of the cytoskeleton and promote various essential cellular functions. Microtubules are dynamic polymers composed of heterodimeric α/ß-tubulin subunits and can assemble de novo in a ‘structural templating’ mechanism assisted by ring-like complexes containing the protein γ-tubuli...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | German |
| Published: |
26 March 2020
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| In: |
Biospektrum
Year: 2020, Volume: 26, Issue: 2, Pages: 145-147 |
| ISSN: | 1868-6249 |
| DOI: | 10.1007/s12268-020-1341-2 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s12268-020-1341-2
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| Author Notes: | Stefan Pfeffer, Elmar Schiebel |
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| 520 | |a Microtubules are part of the cytoskeleton and promote various essential cellular functions. Microtubules are dynamic polymers composed of heterodimeric α/ß-tubulin subunits and can assemble de novo in a ‘structural templating’ mechanism assisted by ring-like complexes containing the protein γ-tubulin. Recent cryo-electron microscopy structures of such γ-tubulin ring complexes from vertebrates propelled our understanding of their architecture, assembly and activation mechanism. | ||
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