Current standards and future directions for prostate cancer radiation therapy
Definitive radiation therapy is a well-recognized curative treatment option for localized prostate cancer. A suitable technique, dose, target volume and the option of a combination with androgen deprivation therapy need to be considered. An optimal standard external beam radiotherapy currently inclu...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2013
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| In: |
Expert review of anticancer therapy
Year: 2013, Volume: 13, Issue: 1, Pages: 75-88 |
| ISSN: | 1744-8328 |
| DOI: | 10.1586/era.12.156 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1586/era.12.156
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| Author Notes: | Michael Pinkawa, Felix Schoth, Dirk Böhmer, Gencay Hatiboglu, Andrew Sharabi, Danny Song & Michael J Eble |
| Summary: | Definitive radiation therapy is a well-recognized curative treatment option for localized prostate cancer. A suitable technique, dose, target volume and the option of a combination with androgen deprivation therapy need to be considered. An optimal standard external beam radiotherapy currently includes intensity-modulated and image-guided radiotherapy techniques with total doses of ≥76-78 Gy in conventional fractionation. Protons or carbon ions are alternatives available only in specific centers. Data from several randomized studies increasingly support the rationale for hypofractionated radiotherapy. A simultaneous integrated boost with dose escalation focused on a computed tomography/PET- or MRI/magnetic resonance spectroscopy-detected malignant lesion is one option to increase tumor control, with potentially no additional toxicity. The application of a spacer is a promising concept for optimal protection of the rectal wall. |
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| Item Description: | Published online: 10 Jan 2014 Gesehen am 24.11.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1744-8328 |
| DOI: | 10.1586/era.12.156 |