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Spatial correlation between traversal and cellular response in ion radiotherapy: towards single track spectroscopy

Knowledge about the mechanisms linking physical energy deposition and biological response in ion cancer beam therapy and space research is still limited. We sought to develop a novel detector system based on fluorescent nuclear track detector (FNTD) covered with a viable cell-layer to gain spatial c...

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Hauptverfasser: Niklas, Martin Anthony (VerfasserIn) , Melzig, Claudius (VerfasserIn) , Abdollahi, Amir (VerfasserIn) , Bartz, J. (VerfasserIn) , Akselrod, M. S. (VerfasserIn) , Debus, Jürgen (VerfasserIn) , Jäkel, Oliver (VerfasserIn) , Greilich, Steffen (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 21 February 2013
In: Radiation measurements
Year: 2013, Jahrgang: 56, Pages: 285-289
ISSN:1879-0925
DOI:10.1016/j.radmeas.2013.01.060
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.radmeas.2013.01.060
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1350448713000838
Volltext
Verfasserangaben:M. Niklas, C. Melzig, A. Abdollahi, J. Bartz, M.S. Akselrod, J. Debus, O. Jäkel, S. Greilich
Beschreibung
Zusammenfassung:Knowledge about the mechanisms linking physical energy deposition and biological response in ion cancer beam therapy and space research is still limited. We sought to develop a novel detector system based on fluorescent nuclear track detector (FNTD) covered with a viable cell-layer to gain spatial correlation between ion traversal and cellular damage on a μm scale. We investigated the possibility to gain, in addition to track location, information on ion type and energy from a single particle track by the FNTD read-out. To access both parameters we aimed to find surrogates for the local energy transfer (LET) of the incident ion and the maximum secondary electron range in the detector material as those quantities are related to the ion type and energy. We parametrized the intensity profile of the fluorescent signal of a single ion by the maximum intensity signal and full width half maximum (FWHM). The first seems to be a suitable surrogate for the LET of the incident particle whereas the latter is only a limited measure for the maximum secondary electron range in detector material.
Beschreibung:Gesehen am 25.11.2021
Beschreibung:Online Resource
ISSN:1879-0925
DOI:10.1016/j.radmeas.2013.01.060

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