Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCC
Head and neck squamous cell carcinoma (HNSCC) patients frequently develop treatment resistance to cetuximab, a monoclonal antibody against EGFR, as well as radiotherapy. Here we addressed extracellular signal-regulated kinase 1/2 (ERK1/2) regulation by cetuximab or fractionated irradiation (IR) and...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
19 May 2020
|
| In: |
British journal of cancer
Year: 2020, Jahrgang: 123, Heft: 2, Pages: 288-297 |
| ISSN: | 1532-1827 |
| DOI: | 10.1038/s41416-020-0892-9 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41416-020-0892-9 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41416-020-0892-9 
|
| Verfasserangaben: | Chao Rong, Marie F. Muller, Fang Xiang, Alexandra Jensen, Wilko Weichert, Gerald Major, Peter K. Plinkert, Jochen Hess and Annette Affolter |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1779101147 | ||
| 003 | DE-627 | ||
| 005 | 20220208224936.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 211125s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41416-020-0892-9 |2 doi | |
| 035 | |a (DE-627)1779101147 | ||
| 035 | |a (DE-599)KXP1779101147 | ||
| 035 | |a (OCoLC)1295680112 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Rong, Chao |d 1986- |e VerfasserIn |0 (DE-588)1127247433 |0 (DE-627)881669199 |0 (DE-576)485140799 |4 aut | |
| 245 | 1 | 0 | |a Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCC |c Chao Rong, Marie F. Muller, Fang Xiang, Alexandra Jensen, Wilko Weichert, Gerald Major, Peter K. Plinkert, Jochen Hess and Annette Affolter |
| 264 | 1 | |c 19 May 2020 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.11.2021 | ||
| 520 | |a Head and neck squamous cell carcinoma (HNSCC) patients frequently develop treatment resistance to cetuximab, a monoclonal antibody against EGFR, as well as radiotherapy. Here we addressed extracellular signal-regulated kinase 1/2 (ERK1/2) regulation by cetuximab or fractionated irradiation (IR) and conducted in silico prognostic evaluation of the EGFR-MAPK axis in HNSCC. | ||
| 650 | 4 | |a Head and neck cancer | |
| 650 | 4 | |a Molecular medicine | |
| 650 | 4 | |a Prognostic markers | |
| 700 | 1 | |a Muller, Marie France |d 1990- |e VerfasserIn |0 (DE-588)1167199138 |0 (DE-627)1030890382 |0 (DE-576)511038704 |4 aut | |
| 700 | 1 | |a Xiang, Fang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jensen, Alexandra |d 1976- |e VerfasserIn |0 (DE-588)136129552 |0 (DE-627)577179020 |0 (DE-576)284704687 |4 aut | |
| 700 | 1 | |a Weichert, Wilko |d 1970-2023 |e VerfasserIn |0 (DE-588)123509106 |0 (DE-627)56134650X |0 (DE-576)293740461 |4 aut | |
| 700 | 1 | |a Major, Gerald |e VerfasserIn |0 (DE-588)1197631372 |0 (DE-627)167931176X |4 aut | |
| 700 | 1 | |a Plinkert, Peter K. |e VerfasserIn |0 (DE-588)1032658509 |0 (DE-627)739933043 |0 (DE-576)169008908 |4 aut | |
| 700 | 1 | |a Heß, Jochen |d 1971- |e VerfasserIn |0 (DE-588)121902390 |0 (DE-627)705696057 |0 (DE-576)292983417 |4 aut | |
| 700 | 1 | |a Affolter, Annette |d 1977- |e VerfasserIn |0 (DE-588)124918417 |0 (DE-627)368073726 |0 (DE-576)294568190 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t British journal of cancer |d Edinburgh : Nature Publ. Group, 1947 |g 123(2020), 2, Seite 288-297 |h Online-Ressource |w (DE-627)320420094 |w (DE-600)2002452-6 |w (DE-576)103746854 |x 1532-1827 |7 nnas |a Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCC |
| 773 | 1 | 8 | |g volume:123 |g year:2020 |g number:2 |g pages:288-297 |g extent:10 |a Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCC |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41416-020-0892-9 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41416-020-0892-9 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20211125 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 124918417 |a Affolter, Annette |m 124918417:Affolter, Annette |d 60000 |d 62100 |e 60000PA124918417 |e 62100PA124918417 |k 0/60000/ |k 1/60000/62100/ |p 9 |y j | ||
| 998 | |g 121902390 |a Heß, Jochen |m 121902390:Heß, Jochen |d 910000 |d 911000 |d 50000 |e 910000PH121902390 |e 911000PH121902390 |e 50000PH121902390 |k 0/910000/ |k 1/910000/911000/ |k 0/50000/ |p 8 | ||
| 998 | |g 1032658509 |a Plinkert, Peter K. |m 1032658509:Plinkert, Peter K. |d 910000 |d 911000 |e 910000PP1032658509 |e 911000PP1032658509 |k 0/910000/ |k 1/910000/911000/ |p 7 | ||
| 998 | |g 1197631372 |a Major, Gerald |m 1197631372:Major, Gerald |d 910000 |d 911400 |e 910000PM1197631372 |e 911400PM1197631372 |k 0/910000/ |k 1/910000/911400/ |p 6 | ||
| 998 | |g 136129552 |a Jensen, Alexandra |m 136129552:Jensen, Alexandra |d 50000 |e 50000PJ136129552 |k 0/50000/ |p 4 | ||
| 998 | |g 1127247433 |a Rong, Chao |m 1127247433:Rong, Chao |p 1 |x j | ||
| 999 | |a KXP-PPN1779101147 |e 4007736650 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCC","title_sort":"Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCC"}],"language":["eng"],"name":{"displayForm":["Chao Rong, Marie F. Muller, Fang Xiang, Alexandra Jensen, Wilko Weichert, Gerald Major, Peter K. Plinkert, Jochen Hess and Annette Affolter"]},"person":[{"family":"Rong","given":"Chao","role":"aut","display":"Rong, Chao"},{"family":"Muller","role":"aut","given":"Marie France","display":"Muller, Marie France"},{"family":"Xiang","role":"aut","given":"Fang","display":"Xiang, Fang"},{"given":"Alexandra","role":"aut","display":"Jensen, Alexandra","family":"Jensen"},{"display":"Weichert, Wilko","given":"Wilko","role":"aut","family":"Weichert"},{"given":"Gerald","role":"aut","display":"Major, Gerald","family":"Major"},{"display":"Plinkert, Peter K.","given":"Peter K.","role":"aut","family":"Plinkert"},{"family":"Heß","display":"Heß, Jochen","role":"aut","given":"Jochen"},{"family":"Affolter","display":"Affolter, Annette","given":"Annette","role":"aut"}],"recId":"1779101147","origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"19 May 2020"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1038/s41416-020-0892-9"],"eki":["1779101147"]},"physDesc":[{"extent":"10 S."}],"relHost":[{"title":[{"title_sort":"British journal of cancer","subtitle":"BJC","title":"British journal of cancer"}],"part":{"issue":"2","pages":"288-297","extent":"10","year":"2020","text":"123(2020), 2, Seite 288-297","volume":"123"},"language":["eng"],"pubHistory":["Volume 1, issue 1 (1 March 1947)-"],"id":{"issn":["1532-1827"],"zdb":["2002452-6"],"eki":["320420094"]},"disp":"Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCCBritish journal of cancer","physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 27.10.25"],"recId":"320420094","origin":[{"publisherPlace":"Edinburgh ; Edinburgh","dateIssuedKey":"1947","publisher":"Nature Publ. Group ; Churchill Livingstone","dateIssuedDisp":"1947-"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"titleAlt":[{"title":"BJC"}]}],"note":["Gesehen am 25.11.2021"]} | ||
| SRT | |a RONGCHAOMUADAPTIVEER1920 | ||