Histone deacetylase 10 promotes autophagy-mediated cell survival

Tumor cells activate autophagy in response to chemotherapy-induced DNA damage as a survival program to cope with metabolic stress. Here, we provide in vitro and in vivo evidence that histone deacetylase (HDAC)10 promotes autophagy-mediated survival in neuroblastoma cells. We show that both knockdown...

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Bibliographic Details

Main Authors:	Oehme, Ina (Author) , Linke, Jan-Peter (Author) , Böck, Barbara (Author) , Milde, Till (Author) , Lodrini, Marco (Author) , Hartenstein, Bettina (Author) , Rettig, Inga Edeltraud (Author) , Eckert, Christian (Author) , Roth, Wilfried (Author) , Kool, Marcel (Author) , Kaden, Sylvia (Author) , Gröne, Hermann-Josef (Author) , Schulte, Johannes Hubertus (Author) , Lindner, Sven (Author) , Hamacher-Brady, Anne (Author) , Brady, Nathan (Author) , Deubzer, Hedwig (Author) , Witt, Olaf (Author)
Format:	Article (Journal)
Language:	English
Published:	June 25, 2013
In:	Proceedings of the National Academy of Sciences of the United States of America Year: 2013, Volume: 110, Issue: 28, Pages: E2592-E2601
ISSN:	1091-6490
DOI:	10.1073/pnas.1300113110
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1073/pnas.1300113110 Verlag, lizenzpflichtig, Volltext: https://www.pnas.org/content/110/28/E2592
Author Notes:	Ina Oehme, Jan-Peter Linke, Barbara C. Böck, Till Milde, Marco Lodrini, Bettina Hartenstein, Inga Wiegand, Christian Eckert, Wilfried Roth, Marcel Kool, Sylvia Kaden, Hermann-Josef Gröne, Johannes H. Schulte, Sven Lindner, Anne Hamacher-Brady, Nathan R. Brady, Hedwig E. Deubzer, and Olaf Witt