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APOS - antibiotic prophylaxis for preventing infectious complications in orthognathic surgery: study protocol for a phase III, multicentre, randomised, controlled, double blinded, clinical trial with two parallel study arms

It is a constant debate among surgeons whether the use of prolonged postoperative antibiotics may reduce surgical site infection rates. As specific treatment guidelines are still lacking, many surgeons continue to use broad-spectrum antibiotics, causing not only increased costs but also contributing...

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Bibliographische Detailangaben
Hauptverfasser: Ristow, Oliver (VerfasserIn) , Hofele, Christof (VerfasserIn) , Münch, Philipp (VerfasserIn) , Danner, Sylvia (VerfasserIn) , Dietzel, Anja (VerfasserIn) , Krisam, Johannes (VerfasserIn) , Klose, Christina (VerfasserIn) , Pilz, Maximilian (VerfasserIn) , Hoffmann, Jürgen (VerfasserIn) , Freudlsperger, Christian (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 02 November 2021
In: Trials
Year: 2021, Jahrgang: 22, Pages: 1-15
ISSN:1468-6694
DOI:10.1186/s13063-021-05710-x
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13063-021-05710-x
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Verfasserangaben:Oliver Ristow, Christof Hofele, Philipp Münch, Sylvia Danner, Anja Dietzel, Johannes Krisam, Christina Klose, Maximilian Pilz, Jürgen Hoffmann and Christian Freudlsperger
Beschreibung
Zusammenfassung:It is a constant debate among surgeons whether the use of prolonged postoperative antibiotics may reduce surgical site infection rates. As specific treatment guidelines are still lacking, many surgeons continue to use broad-spectrum antibiotics, causing not only increased costs but also contributing to the potential for antibiotic resistance. Hence, there is an urgent need for an appropriately designed prospective clinical trial, to investigate whether a prophylactic use of antibiotics after surgery actually decreases surgical site infections to a clinically relevant degree.
Beschreibung:Gesehen am 01.12.2021
Beschreibung:Online Resource
ISSN:1468-6694
DOI:10.1186/s13063-021-05710-x

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