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Phagocytosis by stroma confounds coculture studies

Signals provided by the microenvironment can modify and circumvent pathway activities that are therapeutically targeted by drugs. Bone marrow stromal cell coculture models are frequently used to study the influence of the bone marrow niche on ex vivo drug response. Here, we show that mesenchymal str...

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Main Authors: Herbst, Sophie (Author) , Stolarczyk, Marta (Author) , Becirovic, Tina (Author) , Czernilofsky, Felix (Author) , Liu, Yi (Author) , Kolb, Carolin (Author) , Knoll, Mareike (Author) , Herling, Marco (Author) , Müller-Tidow, Carsten (Author) , Dietrich, Sascha (Author)
Format: Article (Journal)
Language:English
Published: 30 August 2021
In: iScience
Year: 2021, Volume: 24, Issue: 9, Pages: 1-15
ISSN:2589-0042
DOI:10.1016/j.isci.2021.103062
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.isci.2021.103062
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2589004221010300
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Author Notes:Sophie A. Herbst, Marta Stolarczyk, Tina Becirovic, Felix Czernilofsky, Yi Liu, Carolin Kolb, Mareike Knoll, Marco Herling, Carsten Müller-Tidow, and Sascha Dietrich

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