Electrodiffusion models of neurons and extracellular space using the Poisson-Nernst-Planck equations: numerical simulation of the intra- and extracellular potential for an axon model
In neurophysiology, extracellular signals—as measured by local field potentials (LFP) or electroencephalography—are of great significance. Their exact biophysical basis is, however, still not fully understood. We present a three-dimensional model exploiting the cylinder symmetry of a single axon in...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2 July 2013
|
| In: |
Biophysical journal
Year: 2013, Jahrgang: 105, Heft: 1, Pages: 242-254 |
| ISSN: | 1542-0086 |
| DOI: | 10.1016/j.bpj.2013.05.041 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.bpj.2013.05.041 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0006349513006280 
|
| Verfasserangaben: | Jurgis Pods, Johannes Schönke, and Peter Bastian |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1780180330 | ||
| 003 | DE-627 | ||
| 005 | 20220820085243.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 211203s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.bpj.2013.05.041 |2 doi | |
| 035 | |a (DE-627)1780180330 | ||
| 035 | |a (DE-599)KXP1780180330 | ||
| 035 | |a (OCoLC)1341434623 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 29 |2 sdnb | ||
| 100 | 1 | |a Pods, Jurgis |e VerfasserIn |0 (DE-588)105441047X |0 (DE-627)791502031 |0 (DE-576)410251283 |4 aut | |
| 245 | 1 | 0 | |a Electrodiffusion models of neurons and extracellular space using the Poisson-Nernst-Planck equations |b numerical simulation of the intra- and extracellular potential for an axon model |c Jurgis Pods, Johannes Schönke, and Peter Bastian |
| 264 | 1 | |c 2 July 2013 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 03.12.2021 | ||
| 520 | |a In neurophysiology, extracellular signals—as measured by local field potentials (LFP) or electroencephalography—are of great significance. Their exact biophysical basis is, however, still not fully understood. We present a three-dimensional model exploiting the cylinder symmetry of a single axon in extracellular fluid based on the Poisson-Nernst-Planck equations of electrodiffusion. The propagation of an action potential along the axonal membrane is investigated by means of numerical simulations. Special attention is paid to the Debye layer, the region with strong concentration gradients close to the membrane, which is explicitly resolved by the computational mesh. We focus on the evolution of the extracellular electric potential. A characteristic up-down-up LFP waveform in the far-field is found. Close to the membrane, the potential shows a more intricate shape. A comparison with the widely used line source approximation reveals similarities and demonstrates the strong influence of membrane currents. However, the electrodiffusion model shows another signal component stemming directly from the intracellular electric field, called the action potential echo. Depending on the neuronal configuration, this might have a significant effect on the LFP. In these situations, electrodiffusion models should be used for quantitative comparisons with experimental data. | ||
| 700 | 1 | |a Schönke, Johannes |e VerfasserIn |0 (DE-588)141630620 |0 (DE-627)63039749X |0 (DE-576)324485859 |4 aut | |
| 700 | 1 | |a Bastian, Peter |d 1964- |e VerfasserIn |0 (DE-588)1045599794 |0 (DE-627)774643374 |0 (DE-576)399098224 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biophysical journal |d Cambridge, Mass. : Cell Press, 1960 |g 105(2013), 1 vom: 2. Juli, Seite 242-254 |h Online-Ressource |w (DE-627)270425357 |w (DE-600)1477214-0 |w (DE-576)091017602 |x 1542-0086 |7 nnas |a Electrodiffusion models of neurons and extracellular space using the Poisson-Nernst-Planck equations numerical simulation of the intra- and extracellular potential for an axon model |
| 773 | 1 | 8 | |g volume:105 |g year:2013 |g number:1 |g day:2 |g month:07 |g pages:242-254 |g extent:13 |a Electrodiffusion models of neurons and extracellular space using the Poisson-Nernst-Planck equations numerical simulation of the intra- and extracellular potential for an axon model |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.bpj.2013.05.041 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0006349513006280 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20211203 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1045599794 |a Bastian, Peter |m 1045599794:Bastian, Peter |d 700000 |d 708000 |e 700000PB1045599794 |e 708000PB1045599794 |k 0/700000/ |k 1/700000/708000/ |p 3 |y j | ||
| 998 | |g 141630620 |a Schönke, Johannes |m 141630620:Schönke, Johannes |d 700000 |d 714000 |d 714200 |e 700000PS141630620 |e 714000PS141630620 |e 714200PS141630620 |k 0/700000/ |k 1/700000/714000/ |k 2/700000/714000/714200/ |p 2 | ||
| 998 | |g 105441047X |a Pods, Jurgis |m 105441047X:Pods, Jurgis |d 700000 |d 708000 |e 700000PP105441047X |e 708000PP105441047X |k 0/700000/ |k 1/700000/708000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1780180330 |e 4013253879 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 03.12.2021"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"recId":"1780180330","title":[{"title_sort":"Electrodiffusion models of neurons and extracellular space using the Poisson-Nernst-Planck equations","subtitle":"numerical simulation of the intra- and extracellular potential for an axon model","title":"Electrodiffusion models of neurons and extracellular space using the Poisson-Nernst-Planck equations"}],"person":[{"family":"Pods","given":"Jurgis","roleDisplay":"VerfasserIn","display":"Pods, Jurgis","role":"aut"},{"family":"Schönke","given":"Johannes","roleDisplay":"VerfasserIn","display":"Schönke, Johannes","role":"aut"},{"given":"Peter","family":"Bastian","role":"aut","display":"Bastian, Peter","roleDisplay":"VerfasserIn"}],"physDesc":[{"extent":"13 S."}],"relHost":[{"name":{"displayForm":["ed. by the Biophysical Society"]},"origin":[{"publisherPlace":"Cambridge, Mass. ; Bethesda, Md. ; New York, NY","dateIssuedKey":"1960","publisher":"Cell Press ; Soc. ; Rockefeller Univ. Press","dateIssuedDisp":"1960-"}],"id":{"issn":["1542-0086"],"zdb":["1477214-0"],"eki":["270425357"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Biophysical journal","subtitle":"BJ","title":"Biophysical journal"}],"note":["Gesehen am 20.05.2020"],"disp":"Electrodiffusion models of neurons and extracellular space using the Poisson-Nernst-Planck equations numerical simulation of the intra- and extracellular potential for an axon modelBiophysical journal","type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"corporate":[{"display":"Biophysical Society","roleDisplay":"Herausgebendes Organ","role":"isb"}],"recId":"270425357","pubHistory":["1.1960/61 -"],"part":{"issue":"1","pages":"242-254","year":"2013","extent":"13","volume":"105","text":"105(2013), 1 vom: 2. Juli, Seite 242-254"},"titleAlt":[{"title":"BJ"}]}],"origin":[{"dateIssuedDisp":"2 July 2013","dateIssuedKey":"2013"}],"id":{"eki":["1780180330"],"doi":["10.1016/j.bpj.2013.05.041"]},"name":{"displayForm":["Jurgis Pods, Johannes Schönke, and Peter Bastian"]}} | ||
| SRT | |a PODSJURGISELECTRODIF2201 | ||