Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single‐cell transcriptomics
Relapsed/refractory multiple myeloma (RRMM) is characterized by a remarkable heterogeneity and high drug resistance. Here, the authors analyse RRMM samples by single-cell RNA-sequencing, revealing molecular features associated with high-risk chromosomal 1q-gain and changes in the tumor microenvironm...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
29 November 2021
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| In: |
Nature Communications
Year: 2021, Volume: 12, Pages: 1-16 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-021-26951-z |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-021-26951-z Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-021-26951-z 
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| Author Notes: | Stephan M. Tirier, Jan-Philipp Mallm, Simon Steiger, Alexandra M. Poos, Mohamed H. S. Awwad, Nicola Giesen, Nicola Casiraghi, Hana Susak, Katharina Bauer, Anja Baumann, Lukas John, Anja Seckinger, Dirk Hose, Carsten Müller-Tidow, Hartmut Goldschmidt, Oliver Stegle, Michael Hundemer, Niels Weinhold, Marc S. Raab & Karsten Rippe |
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