Role of histone deacetylase inhibitors in the treatment of cancer: review
Acetylation and deacetylation of nucleosomal histones play an important role in the modulation of chromatin structure, chromatin function and in the regulation of gene expression. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) are two opposing classes of enzymes, which tightly co...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 1, 2004
|
| In: |
International journal of oncology
Year: 2004, Jahrgang: 25, Heft: 6, Pages: 1509-1519 |
| ISSN: | 1791-2423 |
| DOI: | 10.3892/ijo.25.6.1509 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3892/ijo.25.6.1509 Verlag, lizenzpflichtig, Volltext: https://www.spandidos-publications.com/10.3892/ijo.25.6.1509 
|
| Verfasserangaben: | Shaoping Mei, Anthony D. Ho, Ulrich Mahlknecht |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 178020471X | ||
| 003 | DE-627 | ||
| 005 | 20230427104147.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 211203s2004 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3892/ijo.25.6.1509 |2 doi | |
| 035 | |a (DE-627)178020471X | ||
| 035 | |a (DE-599)KXP178020471X | ||
| 035 | |a (OCoLC)1341434584 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Mei, Shaoping |e VerfasserIn |0 (DE-588)1246946238 |0 (DE-627)1780205597 |4 aut | |
| 245 | 1 | 0 | |a Role of histone deacetylase inhibitors in the treatment of cancer |b review |c Shaoping Mei, Anthony D. Ho, Ulrich Mahlknecht |
| 264 | 1 | |c December 1, 2004 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 03.12.2021 | ||
| 520 | |a Acetylation and deacetylation of nucleosomal histones play an important role in the modulation of chromatin structure, chromatin function and in the regulation of gene expression. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) are two opposing classes of enzymes, which tightly control the equilibrium of histone acetylation. An imbalance in the equilibrium of histone acetylation has been associated with carcinogenesis and cancer progression. So far, a number of structurally distinct classes of compounds have been identified as HDAC inhibitors including the short-chain fatty acids, hydroxamates, cyclic tetrapeptides and benzamides. These compounds lead to an accumulation of acetylated histone proteins both in tumor cells and in normal tissues. HDAC inhibitors are able to activate differentiation, to arrest the cell cycle in G1 and/or G2, and to induce apoptosis in transformed or cancer cells. Attention is currently being drawn to molecular mechanisms involving histone deacetylases. An induction of p21WAF/CIP1 and a suppression of angiogenic stimulating factors have been observed in tumor cells following exposure to HDAC inhibitors. In xenograft models, several HDAC inhibitors have demonstrated antitumor activity with only few side effects. Several clinical trials showed that HDAC inhibitors in well tolerated doses have significant antitumoral activities. A combination of HDAC inhibitors with differentiation-inducing agents and cytotoxic drugs is an innovative therapeutic strategy that carries the potential for significant improvements in the treatment of cancer. | ||
| 700 | 1 | |a Ho, Anthony Dick |d 1948- |e VerfasserIn |0 (DE-588)108692477 |0 (DE-627)504904205 |0 (DE-576)19010466X |4 aut | |
| 700 | 1 | |a Mahlknecht, Ulrich Rudolph |d 1967- |e VerfasserIn |0 (DE-588)114964890 |0 (DE-627)568995538 |0 (DE-576)289814464 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of oncology |d Athens : Spandidos Publ., 1992 |g 25(2004), 6, Seite 1509-1519 |h Online-Ressource |w (DE-627)348586272 |w (DE-600)2079608-0 |w (DE-576)271585528 |x 1791-2423 |7 nnas |a Role of histone deacetylase inhibitors in the treatment of cancer review |
| 773 | 1 | 8 | |g volume:25 |g year:2004 |g number:6 |g pages:1509-1519 |g extent:11 |a Role of histone deacetylase inhibitors in the treatment of cancer review |
| 856 | 4 | 0 | |u https://doi.org/10.3892/ijo.25.6.1509 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.spandidos-publications.com/10.3892/ijo.25.6.1509 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20211203 | ||
| 993 | |a Article | ||
| 994 | |a 2004 | ||
| 998 | |g 114964890 |a Mahlknecht, Ulrich Rudolph |m 114964890:Mahlknecht, Ulrich Rudolph |d 910000 |d 910100 |e 910000PM114964890 |e 910100PM114964890 |k 0/910000/ |k 1/910000/910100/ |p 3 |y j | ||
| 998 | |g 108692477 |a Ho, Anthony Dick |m 108692477:Ho, Anthony Dick |d 910000 |d 910100 |e 910000PH108692477 |e 910100PH108692477 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 1246946238 |a Mei, Shaoping |m 1246946238:Mei, Shaoping |d 910000 |d 910100 |e 910000PM1246946238 |e 910100PM1246946238 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN178020471X |e 401350264X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Role of histone deacetylase inhibitors in the treatment of cancer","subtitle":"review","title_sort":"Role of histone deacetylase inhibitors in the treatment of cancer"}],"language":["eng"],"person":[{"role":"aut","given":"Shaoping","display":"Mei, Shaoping","family":"Mei"},{"family":"Ho","given":"Anthony Dick","display":"Ho, Anthony Dick","role":"aut"},{"role":"aut","given":"Ulrich Rudolph","display":"Mahlknecht, Ulrich Rudolph","family":"Mahlknecht"}],"name":{"displayForm":["Shaoping Mei, Anthony D. Ho, Ulrich Mahlknecht"]},"origin":[{"dateIssuedDisp":"December 1, 2004","dateIssuedKey":"2004"}],"recId":"178020471X","note":["Gesehen am 03.12.2021"],"relHost":[{"title":[{"title_sort":"International journal of oncology","title":"International journal of oncology"}],"name":{"displayForm":["University of Crete, Faculty of Medicine, Laboratory of Clinical Virology"]},"origin":[{"publisherPlace":"Athens ; Heraklion","publisher":"Spandidos Publ. ; Univ. of Crete","dateIssuedDisp":"[1992]-"}],"note":["Volltext auch als Teil einer Datenbank verfügbar","Gesehen am 12.06.2025"],"id":{"eki":["348586272"],"zdb":["2079608-0"],"issn":["1791-2423"]},"part":{"issue":"6","extent":"11","pages":"1509-1519","year":"2004","volume":"25","text":"25(2004), 6, Seite 1509-1519"},"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"disp":"Role of histone deacetylase inhibitors in the treatment of cancer reviewInternational journal of oncology","recId":"348586272","pubHistory":["Volume 1, issue 1 (June 1992)-"],"type":{"bibl":"periodical","media":"Online-Ressource"}}],"physDesc":[{"extent":"11 S."}],"id":{"eki":["178020471X"],"doi":["10.3892/ijo.25.6.1509"]},"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a MEISHAOPINROLEOFHIST1200 | ||