A small molecule modulating monounsaturated fatty acids and Wnt signaling confers maintenance to induced pluripotent stem cells against endodermal differentiation
Stearoyl-coenzyme A desaturase 1 (SCD1) is required for de novo synthesis of fatty acids. Through the fatty acid acylation process, this enzyme orchestrates post-translational modifications to proteins involved in cell development and differentiation. In this study, we used biochemical methods, immu...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
21 October 2021
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| In: |
Stem cell research & therapy
Year: 2021, Jahrgang: 12, Pages: 1-14 |
| ISSN: | 1757-6512 |
| DOI: | 10.1186/s13287-021-02617-x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13287-021-02617-x
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| Verfasserangaben: | Vahid Hosseini, Ashkan Kalantary-Charvadeh, Maryam Hajikarami, Parisa Fayyazpour, Reza Rahbarghazi, Mehdi Totonchi and Masoud Darabi |
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| 520 | |a Stearoyl-coenzyme A desaturase 1 (SCD1) is required for de novo synthesis of fatty acids. Through the fatty acid acylation process, this enzyme orchestrates post-translational modifications to proteins involved in cell development and differentiation. In this study, we used biochemical methods, immunostaining, and covalent labeling to evaluate whether a small molecule modulating unsaturated fatty acids can influence the early endodermal differentiation of human-induced pluripotent stem cells (iPSCs). | ||
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