A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk
Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis of three GWAS for TL (total n=2240) and selected 1629 variants for replication via the “iCOGS” custom genotyping array. All ∼200...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 29, 2013
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| In: |
Human molecular genetics
Year: 2013, Jahrgang: 22, Heft: 24, Pages: 5056-5064 |
| ISSN: | 1460-2083 |
| DOI: | 10.1093/hmg/ddt355 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/hmg/ddt355 Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/hmg/article/22/24/5056/569757 
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| Verfasserangaben: | Karen A. Pooley, Stig E. Bojesen, Maren Weischer, Sune F. Nielsen, Deborah Thompson, Ali Amin Al Olama, Kyriaki Michailidou, Jonathan P. Tyrer, Sara Benlloch, Judith Brown, Tina Audley, Robert Luben, K-T Khaw, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, Zsofia Kote-Jarai, Caroline Baynes, Mitul Shah, Manjeet K. Bolla, Qin Wang, Joe Dennis, Ed Dicks, Rongxi Yang, Anja Rudolph, Joellen Schildkraut, Jenny Chang-Claude, Barbara Burwinkel, Georgia Chenevix-Trench, Paul D. P. Pharoah, Andrew Berchuck, Rosalind A. Eeles, Douglas F. Easton, Alison M. Dunning, Børge G. Nordestgaard |
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| 245 | 1 | 2 | |a A genome-wide association scan (GWAS) for mean telomere length within the COGS project |b identified loci show little association with hormone-related cancer risk |c Karen A. Pooley, Stig E. Bojesen, Maren Weischer, Sune F. Nielsen, Deborah Thompson, Ali Amin Al Olama, Kyriaki Michailidou, Jonathan P. Tyrer, Sara Benlloch, Judith Brown, Tina Audley, Robert Luben, K-T Khaw, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, Zsofia Kote-Jarai, Caroline Baynes, Mitul Shah, Manjeet K. Bolla, Qin Wang, Joe Dennis, Ed Dicks, Rongxi Yang, Anja Rudolph, Joellen Schildkraut, Jenny Chang-Claude, Barbara Burwinkel, Georgia Chenevix-Trench, Paul D. P. Pharoah, Andrew Berchuck, Rosalind A. Eeles, Douglas F. Easton, Alison M. Dunning, Børge G. Nordestgaard |
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| 520 | |a Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis of three GWAS for TL (total n=2240) and selected 1629 variants for replication via the “iCOGS” custom genotyping array. All ∼200 000 iCOGS variants were analysed with TL, and those displaying associations in healthy controls (n = 15 065) were further tested in breast cancer cases (n = 11 024). We found a novel TL association (Ptrend < 4 × 10−10) at 3p14.4 close to PXK and evidence (Ptrend < 7 × 10−7) for TL loci at 6p22.1 (ZNF311) and 20q11.2 (BCL2L1). We additionally confirmed (Ptrend < 5 × 10−14) the previously reported loci at 3q26.2 (TERC), 5p15.3 (TERT) and 10q24.3 (OBFC1) and found supportive evidence (Ptrend < 5 × 10−4) for the published loci at 2p16.2 (ACYP2), 4q32.2 (NAF1) and 20q13.3 (RTEL1). SNPs tagging these loci explain TL differences of up to 731 bp (corresponding to 18% of total TL in healthy individuals), however, they display little direct evidence for association with breast, ovarian or prostate cancer risks. | ||
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