Cover Image

A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain

Toxins have evolved to target regions of membrane ion channels that underlie ligand binding, gating, or ion permeation, and have thus served as invaluable tools for probing channel structure and function. Here we describe a peptide toxin from the Earth Tiger tarantula that selectively and irreversib...

Full description

Saved in:
Bibliographic Details
Main Authors: Bohlen, Christopher J. (Author) , Priel, Avi (Author) , Zhou, Sharleen (Author) , King, David (Author) , Siemens, Jan (Author) , Julius, David (Author)
Format: Article (Journal)
Language:English
Published: 2010
In: Cell
Year: 2010, Volume: 141, Issue: 5, Pages: 834-845
ISSN:1097-4172
DOI:10.1016/j.cell.2010.03.052
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cell.2010.03.052
Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905675/
Get full text
Author Notes:Christopher J. Bohlen, Avi Priel, Sharleen Zhou, David King, Jan Siemens, and David Julius

MARC

LEADER 00000caa a2200000 c 4500
001 1780383363
003 DE-627
005 20220820090115.0
007 cr uuu---uuuuu
008 211206s2010 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.cell.2010.03.052  |2 doi 
035 |a (DE-627)1780383363 
035 |a (DE-599)KXP1780383363 
035 |a (OCoLC)1341434693 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Bohlen, Christopher J.  |e VerfasserIn  |0 (DE-588)1246979047  |0 (DE-627)1780383762  |4 aut 
245 1 2 |a A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain  |c Christopher J. Bohlen, Avi Priel, Sharleen Zhou, David King, Jan Siemens, and David Julius 
264 1 |c 2010 
300 |a 12 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 06.12.2021 
520 |a Toxins have evolved to target regions of membrane ion channels that underlie ligand binding, gating, or ion permeation, and have thus served as invaluable tools for probing channel structure and function. Here we describe a peptide toxin from the Earth Tiger tarantula that selectively and irreversibly activates the capsaicin- and heat-sensitive channel, TRPV1. This high avidity interaction derives from a unique tandem repeat structure of the toxin that endows it with an antibody-like bivalency, illustrating a new paradigm in toxin structure and evolution. The ‘double-knot’ toxin traps TRPV1 in the open state by interacting with residues in the presumptive pore-forming region of the channel, highlighting the importance of conformational changes in the outer pore region of TRP channels during activation. 
700 1 |a Priel, Avi  |e VerfasserIn  |4 aut 
700 1 |a Zhou, Sharleen  |e VerfasserIn  |4 aut 
700 1 |a King, David  |e VerfasserIn  |4 aut 
700 1 |a Siemens, Jan  |e VerfasserIn  |0 (DE-588)1067334610  |0 (DE-627)818630752  |0 (DE-576)426567323  |4 aut 
700 1 |a Julius, David  |d 1955-  |e VerfasserIn  |0 (DE-588)1242427899  |0 (DE-627)1772275611  |4 aut 
773 0 8 |i Enthalten in  |t Cell  |d [Cambridge, Mass.] : Cell Press, 1974  |g 141(2010), 5, Seite 834-845  |h Online-Ressource  |w (DE-627)320416127  |w (DE-600)2001951-8  |w (DE-576)090881370  |x 1097-4172  |7 nnas  |a A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain 
773 1 8 |g volume:141  |g year:2010  |g number:5  |g pages:834-845  |g extent:12  |a A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain 
856 4 0 |u https://doi.org/10.1016/j.cell.2010.03.052  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905675/  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20211206 
993 |a Article 
994 |a 2010 
998 |g 1067334610  |a Siemens, Jan  |m 1067334610:Siemens, Jan  |p 5 
999 |a KXP-PPN1780383363  |e 4014543072 
BIB |a Y 
SER |a journal 
JSO |a {"name":{"displayForm":["Christopher J. Bohlen, Avi Priel, Sharleen Zhou, David King, Jan Siemens, and David Julius"]},"origin":[{"dateIssuedDisp":"2010","dateIssuedKey":"2010"}],"id":{"doi":["10.1016/j.cell.2010.03.052"],"eki":["1780383363"]},"physDesc":[{"extent":"12 S."}],"relHost":[{"title":[{"title":"Cell","title_sort":"Cell"}],"part":{"text":"141(2010), 5, Seite 834-845","volume":"141","extent":"12","year":"2010","pages":"834-845","issue":"5"},"pubHistory":["1.1974 -"],"language":["eng"],"recId":"320416127","disp":"A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domainCell","type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 11.03.24"],"id":{"issn":["1097-4172"],"zdb":["2001951-8"],"eki":["320416127"]},"origin":[{"dateIssuedDisp":"1974-","publisher":"Cell Press ; Elsevier","dateIssuedKey":"1974","publisherPlace":"[Cambridge, Mass.] ; New York, NY"}],"physDesc":[{"extent":"Online-Ressource"}]}],"person":[{"role":"aut","display":"Bohlen, Christopher J.","roleDisplay":"VerfasserIn","given":"Christopher J.","family":"Bohlen"},{"given":"Avi","family":"Priel","role":"aut","roleDisplay":"VerfasserIn","display":"Priel, Avi"},{"given":"Sharleen","family":"Zhou","role":"aut","display":"Zhou, Sharleen","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"King, David","given":"David","family":"King"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Siemens, Jan","given":"Jan","family":"Siemens"},{"role":"aut","display":"Julius, David","roleDisplay":"VerfasserIn","given":"David","family":"Julius"}],"title":[{"title_sort":"bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain","title":"A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain"}],"note":["Gesehen am 06.12.2021"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1780383363","language":["eng"]} 
SRT |a BOHLENCHRIBIVALENTTA2010 

Similar Items