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Spider toxins activate the capsaicin receptor to produce inflammatory pain

Three peptides isolated from the venom of the West Indian tarantula Psalmopoeus cambridgei have been found to promote pain and inflammation by activating the same neuronal receptor as capsaicin, the hot component of chilli peppers. This suggests that tarantulas and chillis use similar tactics to det...

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Bibliographische Detailangaben
Hauptverfasser: Siemens, Jan (VerfasserIn) , Zhou, Sharleen (VerfasserIn) , Piskorowski, Rebecca (VerfasserIn) , Nikai, Tetsuro (VerfasserIn) , Lumpkin, Ellen A. (VerfasserIn) , Basbaum, Allan I. (VerfasserIn) , King, David (VerfasserIn) , Julius, David (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 09 November 2006
In: Nature
Year: 2006, Jahrgang: 444, Heft: 7116, Pages: 208-212
ISSN:1476-4687
DOI:10.1038/nature05285
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nature05285
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nature05285
Volltext
Verfasserangaben:Jan Siemens, Sharleen Zhou, Rebecca Piskorowski, Tetsuro Nikai, Ellen A. Lumpkin, Allan I. Basbaum, David King, David Julius
Beschreibung
Zusammenfassung:Three peptides isolated from the venom of the West Indian tarantula Psalmopoeus cambridgei have been found to promote pain and inflammation by activating the same neuronal receptor as capsaicin, the hot component of chilli peppers. This suggests that tarantulas and chillis use similar tactics to deter predators. The newly discovered peptides are also unusual because they trigger an excitatory response. Peptides with similar structures that bind to other ion channels are already known, but are inhibitory.
Beschreibung:Gesehen am 06.12.2021
Beschreibung:Online Resource
ISSN:1476-4687
DOI:10.1038/nature05285

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