Graft preservation solution DuraGraft® alleviates vascular dysfunction following in vitro ischemia/reperfusion injury in rats
Vascular ischemia/reperfusion injury (IRI) in patients undergoing coronary artery bypass grafting can result in graft failure and the need for repeat revascularization procedures. DuraGraft® has been shown to protect structure and function in saphenous vein grafts against IRI. We compared the effect...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
9 October 2021
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| In: |
Pharmaceuticals
Year: 2021, Volume: 14, Issue: 10, Pages: 1-9 |
| ISSN: | 1424-8247 |
| DOI: | 10.3390/ph14101028 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ph14101028 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1424-8247/14/10/1028 
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| Author Notes: | Sevil Korkmaz-Icöz, Belinda Ballikaya, Jasmin Soethoff, Patricia Kraft, Alex Ali Sayour, Tamás Radovits, Sivakkanan Loganathan, Matthias Karck, Gábor Szabó and Gábor Veres |
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| 245 | 1 | 0 | |a Graft preservation solution DuraGraft® alleviates vascular dysfunction following in vitro ischemia/reperfusion injury in rats |c Sevil Korkmaz-Icöz, Belinda Ballikaya, Jasmin Soethoff, Patricia Kraft, Alex Ali Sayour, Tamás Radovits, Sivakkanan Loganathan, Matthias Karck, Gábor Szabó and Gábor Veres |
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| 520 | |a Vascular ischemia/reperfusion injury (IRI) in patients undergoing coronary artery bypass grafting can result in graft failure and the need for repeat revascularization procedures. DuraGraft® has been shown to protect structure and function in saphenous vein grafts against IRI. We compared the effect of DuraGraft® to saline solution on arterial grafts submitted to IRI. Rat thoracic aortic rings were harvested and immediately mounted in organ bath chambers (control, n = 7 rats) or underwent cold ischemic preservation either in saline (IR, n = 9 rats) or DuraGraft® (IR+Dura, n = 9 rats). Vascular function was measured ex vivo and immunohistochemistry was performed. Impaired maximum vasorelaxation (Rmax) to ACh in the IR-group compared to controls was ameliorated by DuraGraft®, indicating an improvement in endothelial function (Rmax to ACh (%): IR + Dura 73 ± 2 vs. IR 48 ± 3, p < 0.05). Additionally, decreased aortic ring sensitivity to ACh (pD2-value: -log 50% maximum response) seen after IR in the saline group was increased by DuraGraft® (pD2 to ACh: IR+Dura 7.1 ± 0.1 vs. IR 6.3 ± 0.2, p < 0.05). Impaired maximum contractile response to phenylephrine and high potassium chloride concentrations in the IR group compared to controls was significantly improved by DuraGraft®. DuraGraft® alleviates vascular dysfunction following IRI by reducing nitro-oxidative stress and the expression of ICAM-1, without leukocytes engagement. | ||
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