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Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate

Phosphoinositides are important regulators of intracellular membrane traffic, and although the role of PI(4,5)P2 has been well characterised, the function of PI(3,4)P2 remains unclear; here the formation of PI(3,4)P2 by the class II phosphatidylinositol-3-kinase C2α enzyme is shown to control clathr...

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Main Authors: Posor, York (Author) , Eichhorn-Gruenig, Marielle (Author) , Puchkov, Dmytro (Author) , Schöneberg, Johannes (Author) , Ullrich, Alexander (Author) , Lampe, André (Author) , Müller, Rainer (Author) , Zarbakhsh, Sirus (Author) , Gulluni, Federico (Author) , Hirsch, Emilio (Author) , Krauss, Michael (Author) , Schultz, Carsten (Author) , Schmoranzer, Jan (Author) , Noé, Frank (Author) , Haucke, Volker (Author)
Format: Article (Journal) Editorial
Language:English
Published: 3 July 2013
In: Nature
Year: 2013, Volume: 499, Issue: 7457, Pages: 233-2374
ISSN:1476-4687
DOI:10.1038/nature12360
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nature12360
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nature12360
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Author Notes:York Posor, Marielle Eichhorn-Gruenig, Dmytro Puchkov, Johannes Schöneberg, Alexander Ullrich, André Lampe, Rainer Müller, Sirus Zarbakhsh, Federico Gulluni, Emilio Hirsch, Michael Krauss, Carsten Schultz, Jan Schmoranzer, Frank Noé & Volker Haucke
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Summary:Phosphoinositides are important regulators of intracellular membrane traffic, and although the role of PI(4,5)P2 has been well characterised, the function of PI(3,4)P2 remains unclear; here the formation of PI(3,4)P2 by the class II phosphatidylinositol-3-kinase C2α enzyme is shown to control clathrin-mediated endocytosis.
Item Description:Gesehen am 07.12.2021
Physical Description:Online Resource
ISSN:1476-4687
DOI:10.1038/nature12360

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