Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate
Phosphoinositides are important regulators of intracellular membrane traffic, and although the role of PI(4,5)P2 has been well characterised, the function of PI(3,4)P2 remains unclear; here the formation of PI(3,4)P2 by the class II phosphatidylinositol-3-kinase C2α enzyme is shown to control clathr...
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| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) Editorial |
| Language: | English |
| Published: |
3 July 2013
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| In: |
Nature
Year: 2013, Volume: 499, Issue: 7457, Pages: 233-2374 |
| ISSN: | 1476-4687 |
| DOI: | 10.1038/nature12360 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nature12360 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nature12360 |
| Author Notes: | York Posor, Marielle Eichhorn-Gruenig, Dmytro Puchkov, Johannes Schöneberg, Alexander Ullrich, André Lampe, Rainer Müller, Sirus Zarbakhsh, Federico Gulluni, Emilio Hirsch, Michael Krauss, Carsten Schultz, Jan Schmoranzer, Frank Noé & Volker Haucke |
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| 520 | |a Phosphoinositides are important regulators of intracellular membrane traffic, and although the role of PI(4,5)P2 has been well characterised, the function of PI(3,4)P2 remains unclear; here the formation of PI(3,4)P2 by the class II phosphatidylinositol-3-kinase C2α enzyme is shown to control clathrin-mediated endocytosis. | ||
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