The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres
Constitutive heterochromatin is crucial for the integrity of chromosomes and genomic stability. Here, we show that the chromatin remodelling complex NoRC, known to silence a fraction of rRNA genes, also establishes a repressive heterochromatic structure at centromeres and telomeres, preserving the s...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
25 June 2013
|
| In: |
EMBO reports
Year: 2013, Jahrgang: 14, Heft: 8, Pages: 704-710 |
| ISSN: | 1469-3178 |
| DOI: | 10.1038/embor.2013.87 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/embor.2013.87 Verlag, lizenzpflichtig, Volltext: https://www.embopress.org/doi/full/10.1038/embor.2013.87 
|
| Verfasserangaben: | Anna Postepska-Igielska, Damir Krunic, Nina Schmitt, Karin Maria Greulich-Bode, Petra Boukamp & Ingrid Grummt |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1780638884 | ||
| 003 | DE-627 | ||
| 005 | 20220820091018.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 211208s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/embor.2013.87 |2 doi | |
| 035 | |a (DE-627)1780638884 | ||
| 035 | |a (DE-599)KXP1780638884 | ||
| 035 | |a (OCoLC)1341434634 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Poste̜pska-Igielska, Anna |e VerfasserIn |0 (DE-588)143666479 |0 (DE-627)653841116 |0 (DE-576)337869391 |4 aut | |
| 245 | 1 | 4 | |a The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres |c Anna Postepska-Igielska, Damir Krunic, Nina Schmitt, Karin Maria Greulich-Bode, Petra Boukamp & Ingrid Grummt |
| 264 | 1 | |c 25 June 2013 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.12.2021 | ||
| 520 | |a Constitutive heterochromatin is crucial for the integrity of chromosomes and genomic stability. Here, we show that the chromatin remodelling complex NoRC, known to silence a fraction of rRNA genes, also establishes a repressive heterochromatic structure at centromeres and telomeres, preserving the structural integrity of these repetitive loci. Knockdown of NoRC leads to relaxation of centromeric and telomeric heterochromatin, abnormalities in mitotic spindle assembly, impaired chromosome segregation and enhanced chromosomal instability. The results demonstrate that NoRC safeguards genomic stability by coordinating enzymatic activities that establish features of repressive chromatin at centromeric and telomeric regions, and this heterochromatic structure is required for sustaining genomic integrity. | ||
| 650 | 4 | |a centromeres | |
| 650 | 4 | |a genome stability | |
| 650 | 4 | |a heterochromatin | |
| 650 | 4 | |a NoRC | |
| 650 | 4 | |a telomeres | |
| 700 | 1 | |a Krunic, Damir |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmitt, Nina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Greulich-Bode, Karin Maria |e VerfasserIn |0 (DE-588)173762549 |0 (DE-627)698667409 |0 (DE-576)13460301X |4 aut | |
| 700 | 1 | |a Boukamp, Petra |e VerfasserIn |0 (DE-588)1205902406 |0 (DE-627)1691750824 |4 aut | |
| 700 | 1 | |a Grummt, Ingrid |d 1943- |e VerfasserIn |0 (DE-588)143378724 |0 (DE-627)645139602 |0 (DE-576)33674109X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a European Molecular Biology Organization |t EMBO reports |d [London] : Nature Publishing Group UK, 2000 |g 14(2013), 8 vom: 1. Aug., Seite 704-710 |h Online-Ressource |w (DE-627)320645622 |w (DE-600)2025376-X |w (DE-576)095092153 |x 1469-3178 |7 nnas |
| 773 | 1 | 8 | |g volume:14 |g year:2013 |g number:8 |g day:1 |g month:08 |g pages:704-710 |g extent:7 |a The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres |
| 787 | 0 | 8 | |i Errata |a Poste̜pska-Igielska, Anna |t The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres |d 2013 |w (DE-627)1780641265 |
| 856 | 4 | 0 | |u https://doi.org/10.1038/embor.2013.87 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.embopress.org/doi/full/10.1038/embor.2013.87 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20211208 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 143378724 |a Grummt, Ingrid |m 143378724:Grummt, Ingrid |d 140000 |e 140000PG143378724 |k 0/140000/ |p 6 |y j | ||
| 998 | |g 1205902406 |a Boukamp, Petra |m 1205902406:Boukamp, Petra |d 50000 |e 50000PB1205902406 |k 0/50000/ |p 5 | ||
| 998 | |g 173762549 |a Greulich-Bode, Karin Maria |m 173762549:Greulich-Bode, Karin Maria |d 50000 |d 51001 |e 50000PG173762549 |e 51001PG173762549 |k 0/50000/ |k 1/50000/51001/ |p 4 | ||
| 999 | |a KXP-PPN1780638884 |e 4016852544 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1780638884","name":{"displayForm":["Anna Postepska-Igielska, Damir Krunic, Nina Schmitt, Karin Maria Greulich-Bode, Petra Boukamp & Ingrid Grummt"]},"origin":[{"dateIssuedKey":"2013","dateIssuedDisp":"25 June 2013"}],"id":{"doi":["10.1038/embor.2013.87"],"eki":["1780638884"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"physDesc":[{"extent":"7 S."}],"title":[{"title":"The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres","title_sort":"chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres"}],"person":[{"display":"Poste̜pska-Igielska, Anna","family":"Poste̜pska-Igielska","role":"aut","given":"Anna"},{"given":"Damir","role":"aut","family":"Krunic","display":"Krunic, Damir"},{"family":"Schmitt","given":"Nina","role":"aut","display":"Schmitt, Nina"},{"display":"Greulich-Bode, Karin Maria","given":"Karin Maria","role":"aut","family":"Greulich-Bode"},{"display":"Boukamp, Petra","family":"Boukamp","given":"Petra","role":"aut"},{"display":"Grummt, Ingrid","role":"aut","given":"Ingrid","family":"Grummt"}],"relHost":[{"name":{"displayForm":["European Molecular Biology Organization"]},"recId":"320645622","disp":"European Molecular Biology OrganizationEMBO reports","id":{"doi":["10.1002/(ISSN)1469-3178"],"eki":["320645622"],"issn":["1469-3178"],"zdb":["2025376-X"]},"origin":[{"publisherPlace":"[London] ; Heidelberg ; Oxford [u.a.] ; London [u.a.] ; Hoboken, NJ [u.a.]","publisher":"Nature Publishing Group UK ; EMBO Press ; Oxford Univ. Press ; Nature Publishing Group ; Wiley","dateIssuedDisp":"[2000]-"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"corporate":[{"display":"European Molecular Biology Organization","role":"aut"}],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"title":[{"title":"EMBO reports","title_sort":"EMBO reports"}],"part":{"year":"2013","issue":"8","pages":"704-710","volume":"14","extent":"7","text":"14(2013), 8 vom: 1. Aug., Seite 704-710"},"note":["Fortsetzung der Druck-Ausgabe","Gesehen am 11.03.25"],"pubHistory":["1.2000 -"]}],"note":["Gesehen am 08.12.2021"]} | ||
| SRT | |a POSTEPSKAICHROMATINR2520 | ||