Brain metastases of gastro-oesophageal cancer: evaluation of molecules with relevance for targeted therapies
Background: Brain metastases (BM) of gastro-oesophageal cancer are exceedingly rare and only limited data exist on their pathobiology. Materials and Methods: We identified tissue samples of BM of gastro-oesophageal cancer and analyzed the expression of human epidermal growth factor receptor-2 (HER2)...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 11, 2013
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| In: |
Anticancer research
Year: 2013, Volume: 33, Issue: 3, Pages: 1065-1071 |
| ISSN: | 1791-7530 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://ar.iiarjournals.org/content/33/3/1065
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| Author Notes: | Matthias Preusser, Anna S. Berghoff, Aysegül Ilhan-Mutlu, Carina Dinhof, Manuel Magerle, Christine Marosi, Michael Hejna, David Capper, Andreas Von Deimling, Sebastian F. Schoppmann and Peter Birner |
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| 245 | 1 | 0 | |a Brain metastases of gastro-oesophageal cancer |b evaluation of molecules with relevance for targeted therapies |c Matthias Preusser, Anna S. Berghoff, Aysegül Ilhan-Mutlu, Carina Dinhof, Manuel Magerle, Christine Marosi, Michael Hejna, David Capper, Andreas Von Deimling, Sebastian F. Schoppmann and Peter Birner |
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| 520 | |a Background: Brain metastases (BM) of gastro-oesophageal cancer are exceedingly rare and only limited data exist on their pathobiology. Materials and Methods: We identified tissue samples of BM of gastro-oesophageal cancer and analyzed the expression of human epidermal growth factor receptor-2 (HER2), phosphorylated signal transducer and activator of transcription-3 (pSTAT3), epithelial growth factor receptor (EGFR), V600E point mutation of the v-raf murine sarcoma viral oncogene homolog-B1 (BRAF V600E), cluster of differentiation molecule-34 (CD34), hypoxia inducible factor-1α (HIF 1-α) and Ki-67 by immunohistochemical methods. Results: Our series comprised of twenty adenocarcinomas and one oesophageal squamous cell carcinoma. Three (14%), 7 (33%), 9 (43%), 18 (86%) and 0 BM specimens were scored positively for HER2, EGFR, pSTAT3, HIF1-α and BRAF V600E expression. The median Ki-67 index was 59%. The microvascular density was moderate-to-high and active intratumoral microvascular sprouting was evident in 20/21 (95%) of BMs. The HER2 and EGFR expression status were consistent between primary tumors and BM in all three assessable cases. HIF1-α and pSTAT3 expression were significantly higher in HER2-positive cases. Conclusion: Therapeutic use of agents targeting HER2, pSTAT3, EGFR and angiogenesis may be feasible for selected BM of gastro-esophageal cancer. HER2 positivity does not seem to predispose to brain colonization in gastro-esophageal cancer. | ||
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| 650 | 4 | |a gastro-oesophageal cancer | |
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| 700 | 1 | |a Berghoff, Anna S. |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Dinhof, Carina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Magerle, Manuel |e VerfasserIn |4 aut | |
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