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Brain metastases of gastro-oesophageal cancer: evaluation of molecules with relevance for targeted therapies

Background: Brain metastases (BM) of gastro-oesophageal cancer are exceedingly rare and only limited data exist on their pathobiology. Materials and Methods: We identified tissue samples of BM of gastro-oesophageal cancer and analyzed the expression of human epidermal growth factor receptor-2 (HER2)...

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Hauptverfasser: Preusser, Matthias (VerfasserIn) , Berghoff, Anna S. (VerfasserIn) , Ilhan-Mutlu, Aysegül (VerfasserIn) , Dinhof, Carina (VerfasserIn) , Magerle, Manuel (VerfasserIn) , Marosi, Christine (VerfasserIn) , Hejna, Michael (VerfasserIn) , Capper, David (VerfasserIn) , Deimling, Andreas von (VerfasserIn) , Schoppmann, Sebastian F. (VerfasserIn) , Birner, Peter (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: March 11, 2013
In: Anticancer research
Year: 2013, Jahrgang: 33, Heft: 3, Pages: 1065-1071
ISSN:1791-7530
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://ar.iiarjournals.org/content/33/3/1065
Volltext
Verfasserangaben:Matthias Preusser, Anna S. Berghoff, Aysegül Ilhan-Mutlu, Carina Dinhof, Manuel Magerle, Christine Marosi, Michael Hejna, David Capper, Andreas Von Deimling, Sebastian F. Schoppmann and Peter Birner
Beschreibung
Zusammenfassung:Background: Brain metastases (BM) of gastro-oesophageal cancer are exceedingly rare and only limited data exist on their pathobiology. Materials and Methods: We identified tissue samples of BM of gastro-oesophageal cancer and analyzed the expression of human epidermal growth factor receptor-2 (HER2), phosphorylated signal transducer and activator of transcription-3 (pSTAT3), epithelial growth factor receptor (EGFR), V600E point mutation of the v-raf murine sarcoma viral oncogene homolog-B1 (BRAF V600E), cluster of differentiation molecule-34 (CD34), hypoxia inducible factor-1α (HIF 1-α) and Ki-67 by immunohistochemical methods. Results: Our series comprised of twenty adenocarcinomas and one oesophageal squamous cell carcinoma. Three (14%), 7 (33%), 9 (43%), 18 (86%) and 0 BM specimens were scored positively for HER2, EGFR, pSTAT3, HIF1-α and BRAF V600E expression. The median Ki-67 index was 59%. The microvascular density was moderate-to-high and active intratumoral microvascular sprouting was evident in 20/21 (95%) of BMs. The HER2 and EGFR expression status were consistent between primary tumors and BM in all three assessable cases. HIF1-α and pSTAT3 expression were significantly higher in HER2-positive cases. Conclusion: Therapeutic use of agents targeting HER2, pSTAT3, EGFR and angiogenesis may be feasible for selected BM of gastro-esophageal cancer. HER2 positivity does not seem to predispose to brain colonization in gastro-esophageal cancer.
Beschreibung:Gesehen am 08.12.2021
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Beschreibung:Online Resource
ISSN:1791-7530

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