Kinetics of peripheral blood stem cell mobilization following G-CSF-supported chemotherapy
It would be a clinical and economical advantage if the optimal time point of peripheral blood stem cell (PBSC) mobilization following G-CSF-supported chemotherapy (CT) was known in advance. Therefore, we retrospectively analyzed mobilization parameters in 113 adult tumor patients treated in our inst...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
[September 2003]
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| In: |
Stem cells
Year: 2003, Volume: 21, Issue: 5, Pages: 568-574 |
| ISSN: | 1549-4918 |
| DOI: | 10.1634/stemcells.21-5-568 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1634/stemcells.21-5-568 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1634/stemcells.21-5-568 
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| Author Notes: | Ruth Seggewiss, Eike Christian Buss, Doris Herrmann, Hartmut Goldschmidt, Anthony Dick Ho, Stefan Fruehauf |
| Summary: | It would be a clinical and economical advantage if the optimal time point of peripheral blood stem cell (PBSC) mobilization following G-CSF-supported chemotherapy (CT) was known in advance. Therefore, we retrospectively analyzed mobilization parameters in 113 adult tumor patients treated in our institution within 1 year. The start of apheresis was guided by CD34+ cell measurements in the PB and occurred on or after day 11 after start of mobilization CT in 97% of patients. The median peak (p)CD34+ cell count in PB uniformly occurred on day 14-15 (range: 6-32 days) after the start of CT, irrespective of the diagnosis (multiple myeloma n = 76, other histology n = 37), the type, but not the amount, of premobilization CT or radiotherapy (RT), the mobilization regimen, or the G-CSF dosage administered. Among more heavily pretreated patients (>six cycles of prior CT or RT), a higher proportion mobilized late (pCD34+ cell count later than day 20 in 12% and 13%, respectively, versus 2%-5% in the other groups). Therefore, we propose to start measuring CD34+ cells in the PB on day 11 after the start of mobilization therapy. The wide range of optimal mobilization time points argues for an individualized rather than a preset start of apheresis. |
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| Item Description: | Elektronische Reproduktion der Druckausgabe Gesehen am 10.12.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1549-4918 |
| DOI: | 10.1634/stemcells.21-5-568 |