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Centrosome aberrations in acute myeloid leukemia are correlated with cytogenetic risk profile

Genetic instability is a common feature in acute myeloid leukemia (AML). Centrosome aberrations have been described as a possible cause of aneuploidy in many human tumors. To investigate whether centrosome aberrations correlate with cytogenetic findings in AML, we examined a set of 51 AML samples by...

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Main Authors: Neben, Kai (Author) , Giesecke, Christian (Author) , Schweizer, Silja (Author) , Ho, Anthony Dick (Author) , Krämer, Alwin (Author)
Format: Article (Journal)
Language:English
Published: [1 January 2003]
In: Blood
Year: 2003, Volume: 101, Issue: 1, Pages: 289-291
ISSN:1528-0020
DOI:10.1182/blood-2002-04-1188
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood-2002-04-1188
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0006497120535969
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Author Notes:Kai Neben, Christian Giesecke, Silja Schweizer, Anthony D. Ho, Alwin Krämer

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520 |a Genetic instability is a common feature in acute myeloid leukemia (AML). Centrosome aberrations have been described as a possible cause of aneuploidy in many human tumors. To investigate whether centrosome aberrations correlate with cytogenetic findings in AML, we examined a set of 51 AML samples by using a centrosome-specific antibody to pericentrin. All 51 AML samples analyzed displayed numerical and structural centrosome aberrations (36.0% ± 16.6%) as compared with peripheral blood mononuclear cells from 21 healthy volunteers (5.2% ± 2.0%;P< .0001). In comparison to AML samples with normal chromosome count, the extent of numerical and structural centrosome aberrations was higher in samples with numerical chromosome changes (50.5% ± 14.2% versus 34.3% ± 12.2%;P< .0001). When the frequency of centrosome aberrations was analyzed within cytogenetically defined risk groups, we found a correlation of the extent of centrosome abnormalities to all 3 risk groups (P= .0015), defined as favorable (22.5% ± 7.3%), intermediate (35.3% ± 13.1%), and adverse (50.3% ± 15.6%). These results indicate that centrosome defects may contribute to the acquisition of chromosome aberrations and thereby to the prognosis in AML. 
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