Facile, efficient and diastereoselective synthesis of α-hydrazine tetrazoles through a novel one-pot four-component reaction
A novel and efficient method for the diastereoselective synthesis of α-hydrazine tetrazoles via an isocyanide-based multicomponent reaction is reported in good yields. The α-hydrazine tetrazoles were obtained by a facile azide Ugi four-component reaction (U-4CR) using cyclic ketones, trimethylsilyl...
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| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
25 October 2013
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| In: |
Tetrahedron
Year: 2013, Volume: 69, Issue: 50, Pages: 10718-10723 |
| ISSN: | 1464-5416 |
| DOI: | 10.1016/j.tet.2013.10.062 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tet.2013.10.062 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0040402013016074 |
| Author Notes: | Sorour Ramezanpour, Saeed Balalaie, Frank Rominger, Nahid S. Alavijeh, Hamid Reza Bijanzadeh |
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| 520 | |a A novel and efficient method for the diastereoselective synthesis of α-hydrazine tetrazoles via an isocyanide-based multicomponent reaction is reported in good yields. The α-hydrazine tetrazoles were obtained by a facile azide Ugi four-component reaction (U-4CR) using cyclic ketones, trimethylsilyl azide, hydrazides, and corresponding isocyanide without any catalyst and with high bond forming efficiency at room temperature. | ||
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