Identification and separation of normal hematopoietic stem cells and leukemia stem cells from patients with acute myeloid leukemia
Mounting evidences indicate that leukemic cells in patients with acute myeloid leukemia (AML) are derived from leukemia stem cells (LSC). In analogy to normal hematopoietic stem cells (HSC), LSC remain mostly dormant and are hence resistant to conventional chemotherapy. Residual, physiological HSC e...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Kapitel/Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
13 June 2013
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| In: |
Stem cell niche
Year: 2013, Pages: 217-230 |
| DOI: | 10.1007/978-1-62703-508-8_19 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/978-1-62703-508-8_19
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| Verfasserangaben: | Van T. Hoang, Isabel Hoffmann, Karina Borowski, Abraham Zepeda-Moreno, Dan Ran, Eike C. Buss, Patrick Wuchter, Volker Eckstein, Anthony D. Ho |
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| 245 | 1 | 0 | |a Identification and separation of normal hematopoietic stem cells and leukemia stem cells from patients with acute myeloid leukemia |c Van T. Hoang, Isabel Hoffmann, Karina Borowski, Abraham Zepeda-Moreno, Dan Ran, Eike C. Buss, Patrick Wuchter, Volker Eckstein, Anthony D. Ho |
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| 520 | |a Mounting evidences indicate that leukemic cells in patients with acute myeloid leukemia (AML) are derived from leukemia stem cells (LSC). In analogy to normal hematopoietic stem cells (HSC), LSC remain mostly dormant and are hence resistant to conventional chemotherapy. Residual, physiological HSC exist alongside with LSC, with heterogeneous dominance of LSC over HSC in individual patients. We have devised a flow cytometric method for the identification and separation of these two stem cell populations based on surface antigen markers such as CD34, CD38, lineage aberrant markers, and aldehyde dehydrogenase (ALDH) enzyme activity. | ||
| 650 | 4 | |a Aberrant markers | |
| 650 | 4 | |a Acute myeloid leukemia | |
| 650 | 4 | |a Aldehyde dehydrogenase | |
| 650 | 4 | |a FACS | |
| 650 | 4 | |a Flow cytometry | |
| 650 | 4 | |a Hematopoietic stem cells | |
| 650 | 4 | |a Leukemia stem cells | |
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