Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy
Neurons within the CA3 region of the hippocampus are relatively resistant to cell death after ischemia. Alastair M. Buchan and his colleagues demonstrate that the product of the TSC1 gene, hamartin, is upregulated in CA3 neurons in response to ischemia. Hamartin promotes survival by inhibiting mTORC...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 February 2013
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| In: |
Nature medicine
Year: 2013, Jahrgang: 19, Heft: 3, Pages: 351-357 |
| ISSN: | 1546-170X |
| DOI: | 10.1038/nm.3097 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nm.3097 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nm.3097 
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| Verfasserangaben: | Michalis Papadakis, Gina Hadley, Maria Xilouri, Lisa C. Hoyte, Simon Nagel, M. Mary McMenamin, Grigorios Tsaknakis, Suzanne M. Watt, Cynthia Wright Drakesmith, Ruoli Chen, Matthew J.A. Wood, Zonghang Zhao, Benedikt Kessler, Kostas Vekrellis & Alastair M. Buchan |
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| 520 | |a Neurons within the CA3 region of the hippocampus are relatively resistant to cell death after ischemia. Alastair M. Buchan and his colleagues demonstrate that the product of the TSC1 gene, hamartin, is upregulated in CA3 neurons in response to ischemia. Hamartin promotes survival by inhibiting mTORC1 and increasing autophagic flux in neurons. | ||
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