Ibrutinib for improved chimeric antigen receptor T-cell production for chronic lymphocytic leukemia patients
Chimeric antigen receptor T (CART) cells targeting CD19 have shown promising results in the treatment of chronic lymphocytic leukemia (CLL). However, efficacy seems to be inferior compared to diffuse large B-cell lymphoma or acute lymphoblastic leukemia. Impaired T-cell fitness of CLL patients may b...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2021
|
| In: |
International journal of cancer
Year: 2021, Jahrgang: 148, Heft: 2, Pages: 419-428 |
| ISSN: | 1097-0215 |
| DOI: | 10.1002/ijc.33212 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/ijc.33212 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.33212 
|
| Verfasserangaben: | Fuli Fan, Hyeon Joo Yoo, Sophia Stock, Lei Wang, Yibin Liu, Maria-Luisa Schubert, Sanmei Wang, Brigitte Neuber, Angela Hückelhoven-Krauss, Ulrike Gern, Anita Schmitt, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt, Leopold Sellner |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 178253136X | ||
| 003 | DE-627 | ||
| 005 | 20220215095027.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 211217s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/ijc.33212 |2 doi | |
| 035 | |a (DE-627)178253136X | ||
| 035 | |a (DE-599)KXP178253136X | ||
| 035 | |a (OCoLC)1295644338 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Fan, Fuli |d 1988- |e VerfasserIn |0 (DE-588)119152468X |0 (DE-627)1670144968 |4 aut | |
| 245 | 1 | 0 | |a Ibrutinib for improved chimeric antigen receptor T-cell production for chronic lymphocytic leukemia patients |c Fuli Fan, Hyeon Joo Yoo, Sophia Stock, Lei Wang, Yibin Liu, Maria-Luisa Schubert, Sanmei Wang, Brigitte Neuber, Angela Hückelhoven-Krauss, Ulrike Gern, Anita Schmitt, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt, Leopold Sellner |
| 264 | 1 | |c 2021 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a First published: 19 July 2020 | ||
| 500 | |a Gesehen am 17.12.2021 | ||
| 520 | |a Chimeric antigen receptor T (CART) cells targeting CD19 have shown promising results in the treatment of chronic lymphocytic leukemia (CLL). However, efficacy seems to be inferior compared to diffuse large B-cell lymphoma or acute lymphoblastic leukemia. Impaired T-cell fitness of CLL patients may be involved in treatment failure. Less-differentiated naïve-like T cells play an important role in CART expansion and long-term persistence in vivo. These cells are sparse in CLL patients. Therefore, optimization of CART cell production protocols enriching less differentiated T cell subsets may overcome treatment resistance. The B-cell receptor inhibitor ibrutinib targeting Bruton's tyrosine kinase (BTK) is approved for the treatment of CLL. Besides BTK, ibrutinib additionally inhibits interleukin-2-inducible T-cell kinase (ITK) which is involved in T-cell differentiation. To evaluate the effect of ibrutinib on CART cell production, peripheral blood mononuclear cells from nine healthy donors and eight CLL patients were used to generate CART cells. T-cell expansion and phenotype, expression of homing and exhaustion makers as well as functionality of CART cells were evaluated. CART cell generation in the presence of ibrutinib resulted in increased cell viability and expansion of CLL patient-derived CART cells. Furthermore, ibrutinib enriched CART cells with less-differentiated naïve-like phenotype and decreased expression of exhaustion markers including PD-1, TIM-3 and LAG-3. In addition, ibrutinib increased the cytokine release capacity of CLL patient-derived CART cells. In summary, BTK/ITK inhibition with ibrutinib during CART cell culture can improve yield and function of CLL patient-derived CART cell products. | ||
| 650 | 4 | |a Burton's tyrosine kinase (BTK) | |
| 650 | 4 | |a chimeric antigen receptor (CAR) | |
| 650 | 4 | |a chronic lymphocytic leukemia (CLL) | |
| 650 | 4 | |a ibrutinib | |
| 650 | 4 | |a immunotherapy | |
| 700 | 1 | |a Yoo, Hyeon Joo |e VerfasserIn |0 (DE-588)1196908664 |0 (DE-627)1678777552 |4 aut | |
| 700 | 1 | |a Stock, Sophia |e VerfasserIn |0 (DE-588)1191523071 |0 (DE-627)1670143910 |4 aut | |
| 700 | 1 | |a Wang, Lei |d 1985- |e VerfasserIn |0 (DE-588)1076031994 |0 (DE-627)834093308 |0 (DE-576)444802398 |4 aut | |
| 700 | 1 | |a Liu, Yibin |e VerfasserIn |0 (DE-588)1196909423 |0 (DE-627)1678778311 |4 aut | |
| 700 | 1 | |a Schubert, Maria-Luisa |d 1982- |e VerfasserIn |0 (DE-588)1147867631 |0 (DE-627)1007273801 |0 (DE-576)49608089X |4 aut | |
| 700 | 1 | |a Wang, Sanmei |d 1990- |e VerfasserIn |0 (DE-588)1191709442 |0 (DE-627)1670170527 |4 aut | |
| 700 | 1 | |a Neuber, Brigitte |d 1974- |e VerfasserIn |0 (DE-588)1052913563 |0 (DE-627)789293188 |0 (DE-576)408653884 |4 aut | |
| 700 | 1 | |a Hückelhoven-Krauss, Angela |d 1983- |e VerfasserIn |0 (DE-588)1034095889 |0 (DE-627)744057280 |0 (DE-576)381742822 |4 aut | |
| 700 | 1 | |a Gern, Ulrike |e VerfasserIn |0 (DE-588)1076031390 |0 (DE-627)834091364 |0 (DE-576)444801170 |4 aut | |
| 700 | 1 | |a Schmitt, Anita |d 1969- |e VerfasserIn |0 (DE-588)141722495 |0 (DE-627)630587752 |0 (DE-576)325593892 |4 aut | |
| 700 | 1 | |a Müller-Tidow, Carsten |d 1968- |e VerfasserIn |0 (DE-588)1015101798 |0 (DE-627)705330230 |0 (DE-576)351197893 |4 aut | |
| 700 | 1 | |a Dreger, Peter |e VerfasserIn |0 (DE-588)1028891881 |0 (DE-627)732699894 |0 (DE-576)376320966 |4 aut | |
| 700 | 1 | |a Schmitt, Michael |d 1966- |e VerfasserIn |0 (DE-588)133177173 |0 (DE-627)538000600 |0 (DE-576)299672921 |4 aut | |
| 700 | 1 | |a Sellner, Leopold |d 1984- |e VerfasserIn |0 (DE-588)143493825 |0 (DE-627)646576704 |0 (DE-576)337362963 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of cancer |d Bognor Regis : Wiley-Liss, 1966 |g 148(2021), 2, Seite 419-428 |h Online-Ressource |w (DE-627)269532781 |w (DE-600)1474822-8 |w (DE-576)079876129 |x 1097-0215 |7 nnas |a Ibrutinib for improved chimeric antigen receptor T-cell production for chronic lymphocytic leukemia patients |
| 773 | 1 | 8 | |g volume:148 |g year:2021 |g number:2 |g pages:419-428 |g extent:10 |a Ibrutinib for improved chimeric antigen receptor T-cell production for chronic lymphocytic leukemia patients |
| 856 | 4 | 0 | |u https://doi.org/10.1002/ijc.33212 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.33212 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20211217 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 1076031994 |a Wang, Lei |m 1076031994:Wang, Lei |p 4 | ||
| 998 | |g 143493825 |a Sellner, Leopold |m 143493825:Sellner, Leopold |d 50000 |e 50000PS143493825 |k 0/50000/ |p 15 |y j | ||
| 998 | |g 133177173 |a Schmitt, Michael |m 133177173:Schmitt, Michael |d 910000 |d 910100 |e 910000PS133177173 |e 910100PS133177173 |k 0/910000/ |k 1/910000/910100/ |p 14 | ||
| 998 | |g 1028891881 |a Dreger, Peter |m 1028891881:Dreger, Peter |d 910000 |d 910100 |e 910000PD1028891881 |e 910100PD1028891881 |k 0/910000/ |k 1/910000/910100/ |p 13 | ||
| 998 | |g 1015101798 |a Müller-Tidow, Carsten |m 1015101798:Müller-Tidow, Carsten |d 910000 |d 910100 |e 910000PM1015101798 |e 910100PM1015101798 |k 0/910000/ |k 1/910000/910100/ |p 12 | ||
| 998 | |g 141722495 |a Schmitt, Anita |m 141722495:Schmitt, Anita |d 910000 |d 910100 |d 50000 |e 910000PS141722495 |e 910100PS141722495 |e 50000PS141722495 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 11 | ||
| 998 | |g 1076031390 |a Gern, Ulrike |m 1076031390:Gern, Ulrike |d 910000 |d 910100 |e 910000PG1076031390 |e 910100PG1076031390 |k 0/910000/ |k 1/910000/910100/ |p 10 | ||
| 998 | |g 1034095889 |a Hückelhoven-Krauss, Angela |m 1034095889:Hückelhoven-Krauss, Angela |d 910000 |d 910100 |e 910000PH1034095889 |e 910100PH1034095889 |k 0/910000/ |k 1/910000/910100/ |p 9 | ||
| 998 | |g 1052913563 |a Neuber, Brigitte |m 1052913563:Neuber, Brigitte |d 910000 |d 910100 |e 910000PN1052913563 |e 910100PN1052913563 |k 0/910000/ |k 1/910000/910100/ |p 8 | ||
| 998 | |g 1191709442 |a Wang, Sanmei |m 1191709442:Wang, Sanmei |p 7 | ||
| 998 | |g 1147867631 |a Schubert, Maria-Luisa |m 1147867631:Schubert, Maria-Luisa |d 910000 |d 910100 |e 910000PS1147867631 |e 910100PS1147867631 |k 0/910000/ |k 1/910000/910100/ |p 6 | ||
| 998 | |g 1196909423 |a Liu, Yibin |m 1196909423:Liu, Yibin |d 910000 |d 910100 |e 910000PL1196909423 |e 910100PL1196909423 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 1191523071 |a Stock, Sophia |m 1191523071:Stock, Sophia |p 3 | ||
| 998 | |g 1196908664 |a Yoo, Hyeon Joo |m 1196908664:Yoo, Hyeon Joo |p 2 | ||
| 999 | |a KXP-PPN178253136X |e 4021625372 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["First published: 19 July 2020","Gesehen am 17.12.2021"],"relHost":[{"titleAlt":[{"title":"Predictive oncology"}],"note":["Gesehen am 28.02.08","Darin: Predictive oncology"],"pubHistory":["1.1966 -"],"part":{"text":"148(2021), 2, Seite 419-428","extent":"10","pages":"419-428","volume":"148","issue":"2","year":"2021"},"titleTranslated":[{"translated":"Journal international du cancer"}],"title":[{"title_sort":"International journal of cancer","title":"International journal of cancer","subtitle":"publication of the International Union against Cancer (UICC) = Journal international du cancer"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"corporate":[{"display":"International Union against Cancer","role":"isb"}],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"origin":[{"publisherPlace":"Bognor Regis","publisher":"Wiley-Liss","dateIssuedKey":"1966","dateIssuedDisp":"1966-"}],"id":{"doi":["10.1002/(ISSN)1097-0215"],"zdb":["1474822-8"],"issn":["1097-0215"],"eki":["269532781"]},"recId":"269532781","disp":"Ibrutinib for improved chimeric antigen receptor T-cell production for chronic lymphocytic leukemia patientsInternational journal of cancer"}],"physDesc":[{"extent":"10 S."}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"family":"Fan","given":"Fuli","role":"aut","display":"Fan, Fuli"},{"display":"Yoo, Hyeon Joo","family":"Yoo","given":"Hyeon Joo","role":"aut"},{"role":"aut","given":"Sophia","family":"Stock","display":"Stock, Sophia"},{"display":"Wang, Lei","family":"Wang","role":"aut","given":"Lei"},{"given":"Yibin","role":"aut","family":"Liu","display":"Liu, Yibin"},{"family":"Schubert","role":"aut","given":"Maria-Luisa","display":"Schubert, Maria-Luisa"},{"role":"aut","given":"Sanmei","family":"Wang","display":"Wang, Sanmei"},{"display":"Neuber, Brigitte","role":"aut","given":"Brigitte","family":"Neuber"},{"family":"Hückelhoven-Krauss","given":"Angela","role":"aut","display":"Hückelhoven-Krauss, Angela"},{"display":"Gern, Ulrike","role":"aut","given":"Ulrike","family":"Gern"},{"role":"aut","given":"Anita","family":"Schmitt","display":"Schmitt, Anita"},{"display":"Müller-Tidow, Carsten","role":"aut","given":"Carsten","family":"Müller-Tidow"},{"display":"Dreger, Peter","family":"Dreger","role":"aut","given":"Peter"},{"display":"Schmitt, Michael","family":"Schmitt","role":"aut","given":"Michael"},{"family":"Sellner","role":"aut","given":"Leopold","display":"Sellner, Leopold"}],"title":[{"title":"Ibrutinib for improved chimeric antigen receptor T-cell production for chronic lymphocytic leukemia patients","title_sort":"Ibrutinib for improved chimeric antigen receptor T-cell production for chronic lymphocytic leukemia patients"}],"name":{"displayForm":["Fuli Fan, Hyeon Joo Yoo, Sophia Stock, Lei Wang, Yibin Liu, Maria-Luisa Schubert, Sanmei Wang, Brigitte Neuber, Angela Hückelhoven-Krauss, Ulrike Gern, Anita Schmitt, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt, Leopold Sellner"]},"recId":"178253136X","id":{"eki":["178253136X"],"doi":["10.1002/ijc.33212"]},"origin":[{"dateIssuedDisp":"2021","dateIssuedKey":"2021"}]} | ||
| SRT | |a FANFULIYOOIBRUTINIBF2021 | ||