Effect of increased lactate dehydrogenase A activity and aerobic glycolysis on the proinflammatory profile of autoimmune CD8+ T cells in rheumatoid arthritis
Objective - CD8+ T cells contribute to rheumatoid arthritis (RA) by releasing proinflammatory and cytolytic mediators, even in a challenging hypoxic and nutrient-poor microenvironment such as the synovial membrane.
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2020
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| In: |
Arthritis & rheumatology
Year: 2020, Volume: 72, Issue: 12, Pages: 2050-2064 |
| ISSN: | 2326-5205 |
| DOI: | 10.1002/art.41420 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/art.41420 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/10.1002/art.41420 
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| Author Notes: | M. Margarida Souto-Carneiro, Karel D. Klika, Mónica T. Abreu, André P. Meyer, Rainer Saffrich, Roger Sandhoff, Richard Jennemann, Franziska V. Kraus, Lars Tykocinski, Volker Eckstein, Lina Carvalho, Mark Kriegsmann, Thomas Giese, Hanns-Martin Lorenz, and Rui A. Carvalho |
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| 520 | |a Objective - CD8+ T cells contribute to rheumatoid arthritis (RA) by releasing proinflammatory and cytolytic mediators, even in a challenging hypoxic and nutrient-poor microenvironment such as the synovial membrane. | ||
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