Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia

Increased systemic levels of myeloperoxidase (MPO) are associated with the risk of coronary artery disease (CAD). To identify the genetic factors that are associated with circulating MPO levels, we carried out a genome-wide association study (GWAS) and a gene-centric analysis in subjects of European...

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Main Authors:	Reiner, Alexander P. (Author) , Hartiala, Jaana (Author) , Zeller, Tanja (Author) , Bis, Joshua C. (Author) , Dupuis, Josée (Author) , Fornage, Myriam (Author) , Baumert, Jens (Author) , Kleber, Marcus E. (Author) , Wild, Philipp S. (Author) , Baldus, Stephan (Author) , Bielinski, Suzette J. (Author) , Fontes, João D. (Author) , Illig, Thomas (Author) , Keating, Brendan J. (Author) , Lange, Leslie A. (Author) , Ojeda, Francisco (Author) , Müller-Nurasyid, Martina (Author) , Munzel, Thomas F. (Author) , Psaty, Bruce M. (Author) , Rice, Kenneth (Author) , Rotter, Jerome I. (Author) , Schnabel, Renate B. (Author) , Tang, W.H. Wilson (Author) , Thorand, Barbara (Author) , Erdmann, Jeanette (Author) , Jacobs, David R., Jr (Author) , Wilson, James G. (Author) , Koenig, Wolfgang (Author) , Tracy, Russell P. (Author) , Blankenberg, Stefan (Author) , März, Winfried (Author) , Gross, Myron D. (Author) , Benjamin, Emelia J. (Author) , Hazen, Stanley L. (Author) , Allayee, Hooman (Author)
Format:	Article (Journal)
Language:	English
Published:	April 24, 2013
In:	Human molecular genetics Year: 2013, Volume: 22, Issue: 16, Pages: 3381-3393
ISSN:	1460-2083
DOI:	10.1093/hmg/ddt189
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/hmg/ddt189
Author Notes:	Alexander P. Reiner, Jaana Hartiala, Tanja Zeller, Joshua C. Bis, Josée Dupuis, Myriam Fornage, Jens Baumert, Marcus E. Kleber, Philipp S. Wild, Stephan Baldus, Suzette J. Bielinski, João D. Fontes, Thomas Illig, Brendan J. Keating, Leslie A. Lange, Francisco Ojeda, Martina Müller-Nurasyid, Thomas F. Munzel, Bruce M. Psaty, Kenneth Rice, Jerome I. Rotter, Renate B. Schnabel, W.H. Wilson Tang, Barbara Thorand, Jeanette Erdmann, CARDIoGRAM Consortium, David R. Jacobs Jr, James G. Wilson, Wolfgang Koenig, Russell P. Tracy, Stefan Blankenberg, Winfried März, Myron D. Gross, Emelia J. Benjamin, Stanley L. Hazen and Hooman Allayee