Incidence and clinical significance of 6q deletions in B cell chronic lymphocytic leukemia
Deletions affecting the long arm of chromosome 6 (6q) are among the most commonly observed chromosomal aberrations in lymphoid malignancies and have been identified as adverse prognostic factor in subsets of tumors. Whereas at least two regions of minimal deletion have been established, one in 6q21-...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
09 September 1999
|
| In: |
Leukemia
Year: 1999, Volume: 13, Issue: 9, Pages: 1331-1334 |
| ISSN: | 1476-5551 |
| DOI: | 10.1038/sj.leu.2401499 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/sj.leu.2401499 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/2401499 
|
| Author Notes: | S. Stilgenbauer, L. Bullinger, A. Benner, K. Wildenberger, M. Bentz, K. Döhner, A.D. Ho, P. Lichter, H. Döhner |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1782659579 | ||
| 003 | DE-627 | ||
| 005 | 20220820100404.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 211221s1999 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/sj.leu.2401499 |2 doi | |
| 035 | |a (DE-627)1782659579 | ||
| 035 | |a (DE-599)KXP1782659579 | ||
| 035 | |a (OCoLC)1341436389 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Stilgenbauer, Stephan |d 1966- |e VerfasserIn |0 (DE-588)114728380 |0 (DE-627)590333151 |0 (DE-576)302364781 |4 aut | |
| 245 | 1 | 0 | |a Incidence and clinical significance of 6q deletions in B cell chronic lymphocytic leukemia |c S. Stilgenbauer, L. Bullinger, A. Benner, K. Wildenberger, M. Bentz, K. Döhner, A.D. Ho, P. Lichter, H. Döhner |
| 264 | 1 | |c 09 September 1999 | |
| 300 | |a 4 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.12.2021 | ||
| 520 | |a Deletions affecting the long arm of chromosome 6 (6q) are among the most commonly observed chromosomal aberrations in lymphoid malignancies and have been identified as adverse prognostic factor in subsets of tumors. Whereas at least two regions of minimal deletion have been established, one in 6q21-q23 and another in 6q25-q27, no tumor suppressor gene that might be involved in the pathogenesis of lymphoid malignancies has been so far identified from these segments. For B cell chronic lymphocytic leukemia (B-CLL) conflicting data have been reported regarding the incidence and prognostic significance of 6q deletions. In the current study we have used two YAC clones mapping to deletion regions in bands 6q21 and 6q27 as probes for fluorescence in situ hybridization (FISH) in a large series of B-CLL cases to analyze the incidence, localization and clinical significance of 6q aberrations. Among 285 patients with B-CLL studied we identified 21 cases (7%) with 6q deletions. All deletions were found with the probe mapping to 6q21 while the 6q27 region was deleted only in a third of these cases. Analysis of the clinical characteristics and laboratory parameters showed that the patients with 6q deletions had higher white blood cell counts and more extensive lymphadenopathy. However, the overall survival and the treatment-free intervals were similar in the two groups. We conclude that deletions in 6q21 occur in 7% of B-CLL and identify a subgroup of patients characterized by a larger tumor mass but no inferior outcome. | ||
| 650 | 4 | |a Cancer Research | |
| 650 | 4 | |a general | |
| 650 | 4 | |a Hematology | |
| 650 | 4 | |a Intensive / Critical Care Medicine | |
| 650 | 4 | |a Internal Medicine | |
| 650 | 4 | |a Medicine/Public Health | |
| 650 | 4 | |a Oncology | |
| 700 | 1 | |a Bullinger, Lars |d 1971- |e VerfasserIn |0 (DE-588)121697150 |0 (DE-627)081474296 |0 (DE-576)182046206 |4 aut | |
| 700 | 1 | |a Benner, Axel |d 1959- |e VerfasserIn |0 (DE-588)106584686X |0 (DE-627)81687221X |0 (DE-576)425536602 |4 aut | |
| 700 | 1 | |a Wildenberger, Kathrin |d 1971- |e VerfasserIn |0 (DE-588)133891070 |0 (DE-627)557950503 |0 (DE-576)300174667 |4 aut | |
| 700 | 1 | |a Bentz, Martin |d 1961- |e VerfasserIn |0 (DE-588)1108129226 |0 (DE-627)863748341 |0 (DE-576)475365925 |4 aut | |
| 700 | 1 | |a Döhner, Konstanze |e VerfasserIn |0 (DE-588)1050325176 |0 (DE-627)783856369 |0 (DE-576)404527671 |4 aut | |
| 700 | 1 | |a Ho, Anthony Dick |d 1948- |e VerfasserIn |0 (DE-588)108692477 |0 (DE-627)504904205 |0 (DE-576)19010466X |4 aut | |
| 700 | 1 | |a Lichter, Peter |d 1957- |e VerfasserIn |0 (DE-588)1096366282 |0 (DE-627)856749915 |0 (DE-576)468019049 |4 aut | |
| 700 | 1 | |a Döhner, Hartmut |d 1957- |e VerfasserIn |0 (DE-588)110666585 |0 (DE-627)729880842 |0 (DE-576)375358846 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Leukemia |d London : Springer Nature, 1997 |g 13(1999), 9, Seite 1331-1334 |h Online-Ressource |w (DE-627)32046699X |w (DE-600)2008023-2 |w (DE-576)094139733 |x 1476-5551 |7 nnas |a Incidence and clinical significance of 6q deletions in B cell chronic lymphocytic leukemia |
| 773 | 1 | 8 | |g volume:13 |g year:1999 |g number:9 |g pages:1331-1334 |g extent:4 |a Incidence and clinical significance of 6q deletions in B cell chronic lymphocytic leukemia |
| 856 | 4 | 0 | |u https://doi.org/10.1038/sj.leu.2401499 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/2401499 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20211221 | ||
| 993 | |a Article | ||
| 994 | |a 1999 | ||
| 998 | |g 110666585 |a Döhner, Hartmut |m 110666585:Döhner, Hartmut |d 910000 |d 910100 |e 910000PD110666585 |e 910100PD110666585 |k 0/910000/ |k 1/910000/910100/ |p 9 |y j | ||
| 998 | |g 1096366282 |a Lichter, Peter |m 1096366282:Lichter, Peter |d 50000 |e 50000PL1096366282 |k 0/50000/ |p 8 | ||
| 998 | |g 108692477 |a Ho, Anthony Dick |m 108692477:Ho, Anthony Dick |d 910000 |d 910100 |e 910000PH108692477 |e 910100PH108692477 |k 0/910000/ |k 1/910000/910100/ |p 7 | ||
| 998 | |g 1050325176 |a Döhner, Konstanze |m 1050325176:Döhner, Konstanze |d 910000 |d 910100 |e 910000PD1050325176 |e 910100PD1050325176 |k 0/910000/ |k 1/910000/910100/ |p 6 | ||
| 998 | |g 1108129226 |a Bentz, Martin |m 1108129226:Bentz, Martin |d 910000 |d 910100 |e 910000PB1108129226 |e 910100PB1108129226 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 133891070 |a Wildenberger, Kathrin |m 133891070:Wildenberger, Kathrin |d 910000 |d 910100 |e 910000PW133891070 |e 910100PW133891070 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 106584686X |a Benner, Axel |m 106584686X:Benner, Axel |d 50000 |e 50000PB106584686X |k 0/50000/ |p 3 | ||
| 998 | |g 121697150 |a Bullinger, Lars |m 121697150:Bullinger, Lars |d 50000 |e 50000PB121697150 |k 0/50000/ |p 2 | ||
| 998 | |g 114728380 |a Stilgenbauer, Stephan |m 114728380:Stilgenbauer, Stephan |d 910000 |d 910100 |e 910000PS114728380 |e 910100PS114728380 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1782659579 |e 4023510408 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Stilgenbauer, Stephan","given":"Stephan","family":"Stilgenbauer","role":"aut"},{"role":"aut","family":"Bullinger","display":"Bullinger, Lars","given":"Lars"},{"family":"Benner","role":"aut","given":"Axel","display":"Benner, Axel"},{"given":"Kathrin","display":"Wildenberger, Kathrin","role":"aut","family":"Wildenberger"},{"family":"Bentz","role":"aut","given":"Martin","display":"Bentz, Martin"},{"family":"Döhner","role":"aut","given":"Konstanze","display":"Döhner, Konstanze"},{"given":"Anthony Dick","display":"Ho, Anthony Dick","role":"aut","family":"Ho"},{"role":"aut","family":"Lichter","given":"Peter","display":"Lichter, Peter"},{"display":"Döhner, Hartmut","given":"Hartmut","family":"Döhner","role":"aut"}],"recId":"1782659579","note":["Gesehen am 21.12.2021"],"language":["eng"],"name":{"displayForm":["S. Stilgenbauer, L. Bullinger, A. Benner, K. Wildenberger, M. Bentz, K. Döhner, A.D. Ho, P. Lichter, H. Döhner"]},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2008023-2"],"issn":["1476-5551"],"eki":["32046699X"]},"title":[{"title":"Leukemia","subtitle":"normal and malignant hemopoiesis ; a peer-reviewed journal","title_sort":"Leukemia"}],"origin":[{"publisherPlace":"London ; Basingstoke [u.a.] ; Basingstoke","dateIssuedKey":"1997","dateIssuedDisp":"1997-","publisher":"Springer Nature ; Stockton Press ; Nature Publ. Group"}],"recId":"32046699X","disp":"Incidence and clinical significance of 6q deletions in B cell chronic lymphocytic leukemiaLeukemia","type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"pages":"1331-1334","extent":"4","issue":"9","text":"13(1999), 9, Seite 1331-1334","year":"1999","volume":"13"},"language":["eng"],"pubHistory":["Nachgewiesen 11.1997 -"],"note":["Gesehen am 15.03.04"]}],"origin":[{"dateIssuedKey":"1999","dateIssuedDisp":"09 September 1999"}],"title":[{"title_sort":"Incidence and clinical significance of 6q deletions in B cell chronic lymphocytic leukemia","title":"Incidence and clinical significance of 6q deletions in B cell chronic lymphocytic leukemia"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"extent":"4 S."}],"id":{"eki":["1782659579"],"doi":["10.1038/sj.leu.2401499"]}} | ||
| SRT | |a STILGENBAUINCIDENCEA0919 | ||