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The different immune profiles of normal colonic mucosa in cancer-free Lynch syndrome carriers and Lynch syndrome colorectal cancer patients

Due to the high load of immunogenic frameshift neoantigens, tumors arising in individuals with Lynch syndrome (LS), the most common inherited colorectal cancer (CRC) syndrome, are characterized by a pronounced immune infiltration. However, the immune status of normal colorectal mucosa in LS is not w...

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Main Authors: Bohaumilitzky, Lena (Author) , Kluck, Klaus (Author) , Hüneburg, Robert (Author) , Gallon, Richard (Author) , Nattermann, Jacob (Author) , Kirchner, Martina (Author) , Kristiansen, Glen (Author) , Hommerding, Oliver (Author) , Pfuderer, Pauline Luise (Author) , Wagner, Lelia (Author) , Echterdiek, Fabian Friedrich (Author) , Kösegi, Svenja (Author) , Müller, Nico (Author) , Fischer, Konstantin (Author) , Nelius, Nina (Author) , Hartog, Ben (Author) , Borthwick, Gillian (Author) , Busch, Elena (Author) , Haag, Georg Martin (Author) , Bläker, Hendrik (Author) , Möslein, Gabriela (Author) , Knebel Doeberitz, Magnus von (Author) , Seppälä, Toni T. (Author) , Ahtiainen, Maarit (Author) , Mecklin, Jukka-Pekka (Author) , Bishop, D Timothy (Author) , Burn, John (Author) , Stenzinger, Albrecht (Author) , Budczies, Jan (Author) , Kloor, Matthias (Author) , Ahadova, Aysel (Author)
Format: Article (Journal)
Language:English
Published: 21 February 2022
In: Gastroenterology
Year: 2022, Volume: 162, Issue: 3, Pages: 907-919.e10
ISSN:1528-0012
DOI:10.1053/j.gastro.2021.11.029
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1053/j.gastro.2021.11.029
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0016508521038051
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Author Notes:Lena Bohaumilitzky, Klaus Kluck, Robert Hüneburg, Richard Gallon, Jacob Nattermann, Martina Kirchner, Glen Kristiansen, Oliver Hommerding, Pauline L. Pfuderer, Lelia Wagner, Fabian Echterdiek, Svenja Kösegi, Nico Müller, Konstantin Fischer, Nina Nelius, Ben Hartog, Gillian Borthwick, Elena Busch, Georg Martin Haag, Hendrik Bläker, Gabriela Möslein, Magnus von Knebel Doeberitz, Toni T. Seppälä, Maarit Ahtiainen, Jukka-Pekka Mecklin, D Timothy Bishop, John Burn, Albrecht Stenzinger, Jan Budczies, Matthias Kloor, Aysel Ahadova
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Summary:Due to the high load of immunogenic frameshift neoantigens, tumors arising in individuals with Lynch syndrome (LS), the most common inherited colorectal cancer (CRC) syndrome, are characterized by a pronounced immune infiltration. However, the immune status of normal colorectal mucosa in LS is not well characterized. We assessed the immune infiltrate in tumor-distant normal colorectal mucosa from LS CRC patients, sporadic microsatellite-unstable (MSI) and microsatellite-stable (MSS) CRC patients, and cancer-free LS carriers.
Item Description:Available online 2 December 2021
Gesehen am 24.02.2022
Physical Description:Online Resource
ISSN:1528-0012
DOI:10.1053/j.gastro.2021.11.029

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