Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium

There is a gradient of β-catenin expression along the colonic crypt axis with the highest levels at the crypt bottom. In addition, colorectal cancers show a heterogeneous subcellular pattern of β-catenin accumulation. However, it remains unclear whether different levels of Wnt signalling exert disti...

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Bibliographic Details

Main Authors:	Hirata, Akihiro (Author) , Utikal, Jochen (Author) , Yamashita, Satoshi (Author) , Aoki, Hitomi (Author) , Watanabe, Akira (Author) , Yamamoto, Takuya (Author) , Okano, Hideyuki (Author) , Bardeesy, Nabeel (Author) , Kunisada, Takahiro (Author) , Ushijima, Toshikazu (Author) , Hara, Akira (Author) , Jaenisch, Rudolf (Author) , Hochedlinger, Konrad (Author) , Yamada, Yasuhiro (Author)
Format:	Article (Journal)
Language:	English
Published:	01 January 2013
In:	Development Year: 2013, Volume: 140, Issue: 1, Pages: 66-75
ISSN:	1461-7072
DOI:	10.1242/dev.084103
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1242/dev.084103
Author Notes:	Akihiro Hirata, Jochen Utikal, Satoshi Yamashita, Hitomi Aoki, Akira Watanabe, Takuya Yamamoto, Hideyuki Okano, Nabeel Bardeesy, Takahiro Kunisada, Toshikazu Ushijima, Akira Hara, Rudolf Jaenisch, Konrad Hochedlinger and Yasuhiro Yamada