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Chromothripsis and focal copy number alterations determine poor outcome in malignant melanoma

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Genetic changes during tumorigenesis are usually acquired sequentially. However, a recent study showed that in 2% to 3% of all cancers a single catastrophic event, termed chromothripsis, can lead to massive genomic rearrangements confined to one or a few chromosomes. To explore whether the degree of...

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Main Authors: Hirsch, Daniela (Author) , Kemmerling, Ralf (Author) , Davis, Sean (Author) , Camps, Jordi (Author) , Meltzer, Paul S. (Author) , Ried, Thomas (Author) , Gaiser, Timo (Author)
Format: Article (Journal)
Language:English
Published: March 2013
In: Cancer research
Year: 2013, Volume: 73, Issue: 5, Pages: 1454-1460
ISSN:1538-7445
DOI:10.1158/0008-5472.CAN-12-0928
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/0008-5472.CAN-12-0928
Verlag, lizenzpflichtig, Volltext: https://cancerres.aacrjournals.org/content/73/5/1454
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Author Notes:Daniela Hirsch, Ralf Kemmerling, Sean Davis, Jordi Camps, Paul S. Meltzer, Thomas Ried, and Timo Gaiser
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Chromothripsis and focal copy number alterations determine poor outcome in malignant melanoma by Hirsch, Daniela (Author) , Kemmerling, Ralf (Author) , Davis, Sean (Author) , Camps, Jordi (Author) , Meltzer, Paul S. (Author) , Ried, Thomas (Author) , Gaiser, Timo (Author) ,


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